1. 毕业设计（论文）的内容和要求

本课题根据药物分子的结构要求选取碱性药物为疏水性药物，选取生物相容性的脂肪酸为表面活性剂，对药物-表面活性剂离子对无盐体系进行了研究。

主要研究其聚集行为，物理化学性质，溶血毒性，体外膜通透性、抗肿瘤活性以及体外药物释放动力学等方面。

2. 参考文献

[1]Lasic, D. D.; Application of liposomes. In Handbook of Biological Physics, Lipowsky, R., Sackmann, E., Eds.; Elsevier: Amsterdam, 1993; Vol.l, pp 493. [2] 苑再武. 囊泡的形成、结构及有序结构转变研究[D]. 山东大学, 2006. [3] 周文婷. 表面活性剂囊泡形成的机理研究[D]. 厦门大学, 2007. [4] Tung S H, Lee H Y, Raghavan S R. A Facile Route for Creating ”Reverse” Vesicles: Insights into ”Reverse” Self-Assembly in Organic Liquids[J]. Journal of the American Chemical Society, 2008, 130(27):8813-7. [5] Lee J H. SOFT MATERIALS BASED ON VESICLES AND BIOPOLYMERS[J]. 2006. [6] Lian T, Ho R J. Trends and developments in liposome drug delivery systems.[J]. Journal of Pharmaceutical Sciences, 2001, 90(6):667-80. [7] Lukyanov A N, Elbayoumi T A, Chakilam A R, et al. Tumor-targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody.[J]. Journal of Controlled Release, 2004, 100(1):135-44. [8] Mao M, Huang J, Buyao Zhu A, et al. The Transition from Vesicles to Micelles Induced by Octane in Aqueous Surfactant Two-Phase Systems[J]. Journal of Physical Chemistry B, 2001, 106(1):219-225. [9] Yin H, Lin Y, Huang J, et al. Temperature-induced vesicle aggregation in catanionic surfactant systems: the effects of the headgroup and counterion.[J]. Langmuir the Acs Journal of Surfaces Colloids, 2007, 23(8):4225-4230. [10] Uchegbu I F, Vyas S P. Non-ionic surfactant based vesicles (niosomes) in drug delivery[J]. International Journal of Pharmaceutics, 1998, 172(1#8211;2):33-70. [11] Mehta S K, Jindal N, Kaur G. Quantitative investigation, stability and in vitro release studies of anti-TB drugs in Triton niosomes.[J]. Colloids Surfaces B Biointerfaces, 2011, 87(1):173-179. [12] Discher D E, Eisenberg A. Polymer Vesicles[J]. Science, 2002, 297(5583):967-73. [13] Wang F, Wang Y C, Yan L F, et al. Biodegradable vesicular nanocarriers based on poly(#603;-caprolactone)- block -poly(ethyl ethylene phosphate) for drug delivery[J]. Polymer, 2009, 50(21):5048-5054. [14] Kai Liu, Chao Wang, Prof. Zhibo Li,等. Superamphiphiles Based on Directional Charge-Transfer Interactions: From Supramolecular Engineering to Well-Defined Nanostructures #8224;[J]. Angewandte Chemie International Edition, 2011, 50(21):4952-6. [15] Zhang X, Wang C. Supramolecular amphiphiles[J]. Chemical Society Reviews, 2011, 40(1):94-101. [16] Hassan N, Ruso J M, Pi#241;eiro #225;. Hydrogenated/fluorinated catanionic surfactants as potential templates for nanostructure design.[J]. Langmuir, 2011, 27(16):9719-28. [17] Xu D, Cheng Q. Surface-bound lipid vesicles encapsulating redox species for amperometric biosensing of pore-forming bacterial toxins.[J]. Journal of the American Chemical Society, 2002, 124(48):14314-5. [18] Egli S, Nussbaumer M G, Balasubramanian V, et al. Biocompatible functionalization of polymersome surfaces: a new approach to surface immobilization and cell targeting using polymersomes.[J]. Journal of the American Chemical Society, 2011, 133(12):4476-83. [19] Allen T M, Cullis P R. Drug Delivery Systems: Entering the Mainstream[J]. Science, 2004, 303(5665):1818-22. [20] Boudier A, Castagnos P, Soussan E, et al. Polyvalent catanionic vesicles: exploring the drug delivery mechanisms.[J]. International Journal of Pharmaceutics, 2011, 403(1-2):230-6. [21] Kaler E W, Zasadzinski J A N. Spontaneous vesicle formation in aqueous mixtures of single-tailed surfactants.[J]. Science, 1989, 245(4924):1371-4. [22] 余娜, 任殿福, 刘春丽,等. 阴阳离子表面活性剂复配自发形成囊泡的研究[J]. 吉林大学学报理学版, 2007, 45(4):652-656. [23] Wang X, Danoff E J, Sinkov N A, et al. Highly Efficient Capture and Long-Term Encapsulation of Dye by Catanionic Surfactant Vesicles[J]. Langmuir, 2006, 22(15):6461-4. [24] Consola S, Blanzat M, Perez E, et al. Design of original bioactive formulations based on sugar-surfactant/non-steroidal anti-inflammatory catanionic self-assemblies: a new way of dermal drug delivery.[J]. Chemistry - A European Journal, 2007, 13(11):3039-47.

3. 毕业设计（论文）进程安排

2016.11.21-11.30 与导师会面，布置论文题目及要求 12.1-12.31 查阅资料，完成开题报告和任务书 2017.1.1-1.13 完成翻译，检索相关文献 2.25-3.25 离子对合成 3.26-4.30 结构表征 4.31-5.31 数据整理，书写论文,制作PPT 6.1-6.10 准备论文答辩