1. 毕业设计（论文）的内容和要求

统计二糖或寡糖在蛋白质之催化口袋中的构象发布，表征糖与蛋白质的相对构象与键合模式，构建预测酶催化下的寡糖水解及其变构的模型。

2. 参考文献

1. M. R. Wormald et al., Conformational studies of oligosaccharides and glycoproteins: complementary of NMR, X-ray crystallography, and molecular modeling. Chem. Rev. 2002, 102, 371-386 2. F.A. Quiocho, Carbohydrate-binding proteins: Tertiary structures and proteins-sugar interactions, Ann. Rev. Biochem., 1986 3. A. Imberty et al., Molecular modelling of protein-carbohydrate interactions. Docking of monosaccharides in the binding site of concanavalin A. Glycobiology vol. 1 no. 6 pp. 631-642. 1991 4. Alisdair B. Boraston et al., Differential oligosaccharide recognition by evolutionarily -related beta-1,4 and beta-1,3 glucan-binding modules, J. Mol Biol., 2002 5. Elisa Fadda and Robert J. Woods, Molecular simulations of carbohydrates and protein#8211;carbohydrate interactions：motivation, issues and prospects, Drug Discovery Today Volume 15, Numbers 15/16 August 2010 6. Elizabeth K. Culyba, et al., Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns. 2011; 331:571-5

3. 毕业设计（论文）进程安排

2月中旬-3月中旬：文献检索、数据准备、统计模型准备 3月中旬--5月中旬：数据统计，聚类分析，建模。

5月中旬--六月上旬：论文写作