二茂铁硒-多巴胺衍生物的合成及抗肿瘤活性研究任务书
2020-06-06 11:07:59
1. 毕业设计(论文)的内容和要求
二茂铁化合物由于其稳定、低毒、易修饰和良好的氧化还原性质的特点,被发现是极具潜力的抗癌药物。
而硒不仅作为必需的营养素,提供氧化酶的催化中心,还可作为代谢物的来源直接影响肿瘤的发生。
多巴胺(da)是一种神经传递素,据报道,da通过抑制血管内皮生长因子对肿瘤血管生成和免疫调节作用。
2. 参考文献
[1] Gasser, Gilles; Ott, Ingo; Metzler-Nolte, Nils. Organometallic Anticancer Compounds[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54:3-25 [2] Ornelas, Catia. Application of ferrocene and its derivatives in cancer research[J]. NEW JOURNAL OF CHEMISTRY, 2011,35: 1973-1985 [3] Adams, Muneebah; Li, Yiqun; Khot, Heena. The synthesis and antiparasitic activity of aryl- and ferrocenyl-derived thiosemicarbazone ruthenium(II)-arene complexes[J]. DALTON TRANSACTIONS, 2013,42: 4677-4685 [4] Konrad Kowalski; Aneta Koceva-Chy#322;a; Anna Pieni#261;#380;ek. The synthesis,structure, electrochemistry and invitro anticancer activity studies of ferrocenyl-thymine conjugates[J]. Journal of Organometallic Chemistry, 2012,700:58-68
3. 毕业设计(论文)进程安排
见附件