1. 毕业设计（论文）的内容和要求

二茂铁化合物由于其稳定、低毒、易修饰和良好的氧化还原性质的特点，被发现是极具潜力的抗癌药物。

而硒不仅作为必需的营养素，提供氧化酶的催化中心，还可作为代谢物的来源直接影响肿瘤的发生。

多巴胺（da）是一种神经传递素，据报道，da通过抑制血管内皮生长因子对肿瘤血管生成和免疫调节作用。

2. 参考文献

[1] Qidong Tang, Xin Zhai, Yayi Tu, Ping Wang, Linxiao Wang, Chunjiang Wu, Wenhui Wang, Hongbo Xie, Ping Gong , Pengwu Zheng, Bioorg. Med. Chem. Lett. 26 (2016) 1794#8211;1798 [2]Wei Shi, Benjamin A. Nacev, Blake T. Aftab, Sarah Head, Charles M. Rudin, and Jun O. Liu. J. Med. Chem. 2011, 54, 7363#8211;7374 [3]Yincheng Chang, Kui Yang, Peng Wei, Sisi Huang, Yuxin Pei, Wei Zhao, and Zhichao Pei . Cationic Vesicles Based on Amphiphilic Pillar[5]arene Capped with Ferrocenium: A Redox-Responsive System for Drug/siRNA Co-Delivery. Angew. Chem. Int. Ed. 2014, 53, 13126-13130. [4] Yong-jia Shang, Jian-wei Wu, Chen-li Fan, Jin-song Hu, Ben-ye Lu. Synthesis of 1,3-bis-(5-ferrocenylisoxazole-3-yl) benzene-derived palladium(II) acetate complex and its application in Mizoroki#8211;Heck reaction in an aqueous solution. Journal of Organometallic Chemistry . 2008,693,2963-2966. [5] Sambuddha Banerjee, Aurkie Ray, Soma Sen, Samiran Mitra, David L. Hughes, Ray J. Butcher, Stuart R. Batten, David R. Turner. Pseudohalide-induced structural variations in hydrazone-based metal complexes: Syntheses, electrochemical studies and structural aspects. Inorganica Chimica Acta . 2008,361,2692-2700. [6] Christophe Biot, Wassim Daher, Cheikh M. Ndiaye,Patricia Melnyk, Bruno Pradines, Natascha Chavain, Alain Pellet, Laurent Fraisse, Lydie Pelinski, Christian Jarry, Jacques Brocard, Jamal Khalife, Isabelle Forfar-Bares, Daniel Dive. Probing the Role of the Covalent Linkage of Ferrocene into a Chloroquine Template. J. Med. Chem. 2006,49,4707-4714.

3. 毕业设计（论文）进程安排

见附件