1. 毕业设计（论文）的内容和要求

1．文献查阅从查阅文献着手，通过使用计算机在中国期刊网，维普数据库，超星数字图书馆，美国化学学会（acs）数据库，ca，sci等检索资源上查阅雷诺嗪的制备工艺等相关文献。

熟悉了文献查找的方法和步骤，对以前学者所做的研究进行了了解，并确定自己的研究方向，研究范围。

明确了本次论文所要解决的问题，以及解决途径和拟采用的方法。

2. 参考文献

[1] 刘连友, 于广新, 冯洲. 抗心绞痛药物临床应用的若干进展[J].《日本医学介绍》, 1992, 10(13):477-478. [2] 宋春华. 冠心病心绞痛针灸作用机理研究进展[J]. 针灸临床杂志, 2008,29(04):49-50. [3] Wang P, Z weier J L. Measurement of nitric oxide and peroxynitrite generation in the postischemic heart[J]. J Biol Chem,1996,271(46):29223-29230. [4] 卢晨,王友京.血管活性物质在针灸治疗心脑血管疾病中作用的研究概况[J]. 针刺研究,2004,29(4):304-309. [5] 赵艳玲, 唐晨光, 章薇等. 针药并用治疗冠心病心绞痛临床疗效观察及对血浆ET、CGRP影响的研究[J]. 中国针灸,2001,21(2):70 [6] 肖文星, 石如海. 硝酸酯类药物治疗冠心病的研究进展[J]. 中国全科医学, 2007, 10(10):821-822. [7] Ignarro, Louis J.; Lippton, Howard.; Edwards, James C.;et al. Mechanism o-f vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprussi-de and nitric oxide: evidence for the involvement of S-nitrosothiols as acti-ve intermediates[J]. Journal of Pharmacology and Experimental Therapeuti-cs, 1981, 218(3):739-49. [8] Ignarro Louis J, Cirino Giuseppe, Casini Alessandro, et al. Nitric oxide as a signaling molecule in the vascular system: an overview[J]. Journal of Cardiovascular Pharmacology, 1999, 34(6):879-886. [9] Lei Sizheng Z, Pan Zhuo Hua, Aggarwal Sanjay K, et al. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex[J]. Journal of Integrative Agriculture, 2014, 13(12):2616-2624. [10] Watkins L R, Martin D, Ulrich P, et al. Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat[J]. Pain, 1997, 71(3):225-235. [11] Muller E E, Locatelli V, Cella S, et al. Prolactin lowering and releasing drugs. Mechanisms of action and therapeutic applications[J]. Drugs, 1983, 25(4):399-432. [12] 赵晋, 田茂奎, 唐巍. 环磷腺苷合成工艺研究综述[J]. 科教文汇（上月刊）, 2008,02:198. [13] Lipkin D, Cook W H, Markham Roy. Adenosine-3',5'-phosphoric acid: a proof of structure[J]. Journal of American Chemical Society, 1959, 81:6198-6203. [14] Borden R K, Smith M. Nucleotide synthesis. III. Preparation of nucleoside 3',5'-(cyclic phosphates) in strong base[J]. Journal of Organic Chemistry, 1966, 31(10):3247-3253. [15] Taguchi Y, Mushika Y. Synthetic studies on phosphorylating reagents. IV. Novel synthesis of nucleoside cyclic 3',5'-phosphates by the use of 2-(N,N-dimethylamino)-4-nitrophenyl phosphate[J]. Bulletin of Chemical Society of Japan, 1975, 48(5):1528-1532. [16] Teruaki Mukaiyama, Mitsunori Hashimoto. Synthesis of Oligothymidylates and Nucleoside Cyclic Phosphates by Oxidation-Reduction Condensation[J]. J.Am.Chem.Soc. 1972, 94(24): 8528-8532. [17] M Smith, G I Drummond, H G Khorana. Cyclic Phosphates. IV. Ribonucleoside-3#8217;,5#8217;Cyclic Phosphates, A General Method of Synthesis and Some properties[J]. J.Am.Chem.Soc.1960, 83: 698-706. [18] Genieser H G, Dostmann W, Butt E, et al. Synthesis of nucleoside-3',5'-cyclic phosphorothioates by cyclothiophosphorylation of unprotected nucleosides[J]. Tetrahedron Letters, 1988,29(23):2803-2804. [19] 申艳红, 张文升, 刘启宾等. 环磷腺苷的合成[J]. 中国医药工业杂志, 2004. 35(3):132-133.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 备 注 2017.2.15～2017.3.1 确定课题，查阅文献。

2017.3.2～2017.3.19 研究设计试验方案，熟悉试验细节。

2017.3.20～2017.4.30 建立相关化合物的定性和定量分析方法，并建立实验方法，进行实验。