1. 毕业设计（论文）的内容和要求

静电纺丝法是常见的纳米纤维敷料制备方法之一，其纳米结构可以仿生天然细胞外基质。

目前，大多敷料机械强度低，且抗菌性能差，不能满足实际使用需求。

本课题利用良好的生物可降解性、生物相容性和良好机械强度的聚己内酯，与具有抗菌性的壳聚糖天然高分子，通过调节比例制备具有良好机械性能的抗菌纳米纤维敷料。

2. 参考文献

[1]Y.L. Cui, A.D. Qi, W.G. Liu, X.H. Wang, H. Wang, D.M. Ma, K.D. Yao, Biomimetic surface modification of poly(L-lactic acid) with chitosan and its effects on articular chondrocytes in vitro, Biomaterials 24 (2003) 3859#8211;3868. [2] S.C. Neves, L.S. Moreira-Teixeira, L. Moroni, R.L. Reis, C.A. Van-Blitterswijk, N.M. Alves, M. Karperien, J.F. Mano, Chitosan/poly( -caprolactone) blend scaffolds for cartilage repair, Biomaterials 32 (2011) 1068#8211;1079. [3] N. Bhardwaj, Q.T. Nguyen, A.C. Chen, D.L. Kaplan, R.L. Sah, S.C. Kundu, Potential of 3-D tissue constructs engineered frombovine chondrocytes/silk fibroin-chitosan for in vitro cartilage tissue engineering, Biomaterials 32 (2011) 5773#8211;5781. [4] N. Bhardwaj, S.C. Kundu, Chondrogenic differentiation of rat MSCs on porous scaffolds of silk fibroin/chitosan blends, Biomaterials 33 (2012) 2848#8211;2857. [5] I.L. Shih, Y.T. Van, The production of poly-(γ-glutamic acid) from microorganisms and its various applications, Bioresour. Technol. 79 (2001) 207#8211;225. [6] K.Y. Chang, L.W. Cheng, G.H. Ho, Y.P. Huang, Y.D. Lee, Fabrication and characterization of poly(γ-glutamic acid)-graft-chondroitin sulfate/polycaprolactone porous scaffolds for cartilage tissue engineering, Acta Biomater. 5 (2009) 1937#8211;1947. [7] J. Xu, S. Strandman, J.X.X. Zhu, J. Barralet, M. Cerruti, Genipin-crosslinked catecholchitosan mucoadhesive hydrogels for buccal drug delivery, Biomaterials 37 (2015) 395#8211;404.

3. 毕业设计（论文）进程安排

1. 2017.12-2018.1 文献调研及路线设计； 2. 2018.2-2018.6 实验合成及工艺路线优化； 3. 2018.6 数据整理及论文写作。