1. 毕业设计（论文）的内容和要求

启发式优化算法指的是模拟自然界某一现象或机理的寻优过程，利用计算机语言实现具有相同或类似过程的数值计算及推理，达到解决一定待优化问题的算法或方法。

从生命的最小遗传物质到大的生物群落，目前，世界上优化算法领域内的学者们已相继提出了dna计算、神经网络计算、生物个体计算(如蛙跳算法)、遗传算法、蚁群算法、粒子群算法、蜂群算法等，但作为生命的最基本单元--细胞，却少被研究。

经过上亿年的进化，细胞作为生命的基石，这一”精妙”的机器在生命长河中优胜劣汰的环境中势必有很多优秀的机制便于细胞获取尽可能多的有利能量。

2. 参考文献

[1] Jili Tao, Ning Wang. DNA computing based RNA genetic algorithm with applications in parameter estimation of chemical engineering processes, Computers and Chemical Engineering 31 (2007) 1602#8211;1618. [2] 黄亮. 膜计算优化算法及应用[D]. 杭州：浙江大学博士学位论文，2007. [3] K.T. Wang, N. Wang, A novel RNA genetic algorithm for parameter estimation of dynamic systems. Chemical Engineering Research and Design. 88(2010) 1485-1493. [4] 杨世品. P系统优化算法及应用研究[D]. 杭州：浙江大学博士学位论文， 2012. [5] Linga, P., AI-Saifi, N. and Englezos, P., Comparison of the Luus-Jaakola optimization and Gauss-Newton methods for parameter estimation in ordinary differential equation models. Ind Eng Chem Res, 2006, 45(13):4716-4725. [6] Ardenghi, J.I., Maciel, M.C. and Verdiell, A.B., A trust-region-approach for solving a parameter estimation problem for the biotechnology. Appl Numer Math, 2003, 47:281-294. [7] Leineweber, D.B., Bauer, I., Rock, H.G. and Schl#246;der, J.P., An efficient multiple shooting based reduced SQP strategy for large-scale dynamic process optimization. Part 1: Theoretical aspects. Comput Chem Eng, 2003, 27:157-166. [8] Shipin Yang, Ryad Chellali, Xiaohua Lu, Lijuan Li, Cuimei Bo. Modeling and optimization for proton exchange membrane fuel cell stack using aging and challenging P systems based optimization algorithm. Energy, 2016,109:569-577. (SCI收录, IF:4.292, TOP) [9] Shipin Yang, Ning Wang. A novel P systems based optimization algorithm for parameter estimation of proton exchange membrane fuel cell model. International Journal of Hydrogen Energy.2012,37(10):8465-8476. (SCI收录, IF: 3.548, Top) [10] Shipin Yang, Ning Wang. A P systems based hybrid optimization algorithm for parameter estimation of FCCU reactor-regenerator model. Chemical Engineering Journal. 2012,212:508-518 (SCI收录, IF: 3.473)

3. 毕业设计（论文）进程安排

2018.1.2~2018.1.13 完成开题报告撰写。

2018.1.2~2018.2.30 完成外文文献的翻译。

2018.3.1~2018.3.15 完成课题综述的查询。