1. 毕业设计（论文）的内容和要求

由于 氟系列产品所具有的特殊性能愈来愈受到人们的重视，所以，取代芳烃三氟甲基化研究是近年来有机合成领域一个非常热门的研究课题，本课题主要是针对不同底物进行合成研究，制备出合格产品。

2. 参考文献

[1] Brandi A, Cicchi S, Cordero F M, et al. Heterocycles from Alkylidenecyclopropanes[J]. Cheminform, 2003, 34(26):1213-1269. [2] O'Hagan D. Pyrrole, pyrrolidine, pyridine, piperidine and tropane alkaloids.[J]. Natural Product Reports, 2000, 17(5):435-446. [3] Murata T, Murai M, Lkeda Y, et al. Pd- and Cu-catalyzed one-pot multicomponent synthesis of hetero α,α-dimers of heterocycles [J]. Org. Lett., 2012, 14(9): 2296-2299. [4] Jiang B, Li C, Tu S J, et al. Iodine-Promoted Domino Reaction Leading to N-Substituted 2-Aminoquinoline-3-carbonitriles under Microwave Irradiation[J]. Journal of Combinatorial Chemistry, 2010, 12(4):482-487. [5] 张志刚，吴洪才，易文辉，等. 聚3-辛酰基吡咯的合成及其光学特性研究[J].光电子﹒激光，2004, 15(10): 1214-1217. [6] 张志刚，吴洪才，易文辉. 新型水溶性聚[(3-辛酰基吡咯-2,5-二)对二甲氨基苯甲烯]的合成、表征及性能研究[J]. 高等学校化学学报，2004, 25(12): 2367-2369. [7] Wang M Z, Han X, Qi F, et al. Design, Synthesis, and Fungicidal Activity of Novel Analogues of Pyrrolnitrin[J]. Journal of Agricultural Food Chemistry, 2009, 57(17):7912-7918. [8] Honeywell International, Inc. Process for the synthesis of 3-Hydroxy-3-(2-phenylethyl) hexanoic acid, useful as an intermediate for antiviral drugs: US, 2004110957[P]. 2004-06-10. [9] 中山大学，广州中大创新药物研究与开发中心有限公司．一种丁酸氯维地平的制备方法[P]．中国专利，101759631. 2010-06-30. [10] Song S, Ji C, Min W, et al. Adsorption of Silver(I) from Aqueous Solution by Chelating Resins with 3-Aminopyridine and Hydrophilic Spacer Arms: Equilibrium, Kinetic, Thermodynamic, and Mechanism Studies[J]. Journal of Chemical Engineering Data, 2011, 56(4):1001-1008. [11] Wang Y, Sotzing G A, Weiss R A. Preparation of conductive polypyrrole/polyurethane composite foams by in situ polymerization of pyrrole[J]. Chemistry of Materials, 2008, 20(7): 2574-2582. [12] Jie Y, Feng S, Gong L Z. Broslash;nsted-Acid-Catalyzed Asymmetric Multicomponent Reactions For The Facile Synthesis Of Highly Enantioenriched Structurally Diverse Nitrogenous Heterocycles[J]. Accounts of Chemical Research, 2011, 44(11): 1156-1171. [13] Ruijter E, Scheffelaar R, Orru R V. Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity[J]. Angewandte Chemie International Edition, 2011, 50(28):6234#8211;6246. [14] Heijden G V D, Ruijter E, Orru R V A. Efficiency, Diversity, and Complexity with Multicomponent Reactions[J]. Synlett, 2013, 24(6):666-685. [15]Weber L, Illgen K, Almstetter M. Discovery of New Multi Component Reactions with Combinatorial Methods[J]. Synlett, 1999, 1999(3):366-374. [16] Skraup, Z. H. Ber. Dtsch. Chem. Ges. 1880, 13:2086. [17] Xiao F, Chen Y, Liu Y, et al. Sequential catalytic process: synthesis of quinoline derivatives by AuCl3/CuBr-catalyzed three-component reaction of aldehydes, amines, and alkynes[J]. Cheminform, 2008, 64(12):2755-2761. [18] Cao K, Zhang F M, Tu Y Q, et al. Iron(III)-catalyzed and air-mediated tandem reaction of aldehydes, alkynes and amines: an efficient approach to substituted quinolines.[J]. Chemistry, 2009, 15(26):6332-6334. [19] Sun J. Synthesis of Polysubstituted Dihydropyridines by Four-Component Reactions of Aromatic Aldehydes, Malononitrile, Arylamines, and Acetylenedicarboxylate[J]. Organic Letters, 2010, 12(16):3678-3681. [20] Bartoli G, Bosco M, Galzerano P, et al. Multicomponent Domino Reaction Promoted by Mg(ClO4 ) 2 : Highly Efficient Access to Functionalized 1,4-Dihydropyridines[J]. European Journal of Organic Chemistry, 2008, 2008(23):3970-3975. [21] Georgescu E, Georgescu F, Popa M M, et al. Efficient one-pot, three-component synthesis of a library of pyrrolo[1,2-c]pyrimidine derivatives.[J]. Acs Combinatorial Science, 2012, 14(2):101-107. [22] Darandale S N, Pansare D N, Mulla N A, et al. Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity[J]. Bioorganic Medicinal Chemistry Letters, 2013, 23(9):2632-2635. [23] Strecker A. Uuml;ber die k#252;nstliche Bildung der Milchsauml;ure und einen neuen, dem glycocoll homologen Kouml;rper. Ann Chem . 1850, 75:27-45.

3. 毕业设计（论文）进程安排

2017.12.20 布置论文 2017.12.20-2017.12.30 查阅文献 2018.1.1-2018.1.13 撰写开题报告 2018.2.26-2018.3.3 实验准备工作 2018.3.6-2018.5.31 实验工作 2018.6.1-2018.6.5 撰写论文，准备答辩