1. 毕业设计（论文）的内容和要求

1．文献查阅 掌握文献查阅的一般方法，学会使用计算机在中国期刊网，维普数据库，超星数字图书馆，elsevier、ncbi电子期刊，springer link全文电子期刊，pubmed等检索资源上查阅关于锝-99m以及聚乙烯亚胺/阿霉素络合物的相关文献。

2．文献阅读及综述 阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

1） Branco de Barros, A. L., S. F. de Andrade, et al. (2013). "Radiolabeling of low molecular weight-galactose-based glycodendrimer with technetium-99m and biodistribution studies." Journal of Radioanalytical and Nuclear Chemistry 298(1): 605-609. 2） Jiang, D., M. Wang, et al. (2017). "Multifunctionalized polyethyleneimine-based nanocarriers for gene and chemotherapeutic drug combination therapy through one-step assembly strategy." International Journal of Nanomedicine 12: 8681-8698. 3） Kovacs, L., M. Tassano, et al. (2014). "Labeling polyamidoamine (PAMAM) dendrimers with technetium-99m via hydrazinonicotinamide (HYNIC)." Current radiopharmaceuticals 7(2): 115-122. 4） Lee, Y.-H. and Y.-T. Ma (2017). "Synthesis, characterization, and biological verification of anti-HER2 indocyanine green-doxorubicin-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions for targeted photochemotherapy of breast cancer cells." Journal of Nanobiotechnology 15. 5） Liao, H., H. Liu, et al. (2014). "Antitumor Efficacy of Doxorubicin Encapsulated Within PEGylated Poly( amidoamine) Dendrimers." Journal of Applied Polymer Science 131(11). 6） Luo, Y., L. Zhao, et al. (2016). "The design of a multifunctional dendrimer-based nanoplatform for targeted dual mode SPECT/MR imaging of tumors." Journal of Materials Chemistry B 4(45): 7220-7225. 7） Song, M., Z. Guo, et al. (2017). "Synthesis and preliminary evaluation of a Tc-99m-labeled folate-PAMAM dendrimer for FR imaging." Chemical Biology Drug Design 89(5): 755-761. 8） Wang, Y., R. Guo, et al. (2011). "Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy." Biomaterials 32(12): 3322-3329. 9） Xiao, S., R. Castro, et al. (2016). "Fine tuning of the pH-sensitivity of laponite-doxorubicin nanohybrids by polyelectrolyte multilayer coating." Materials Science Engineering C-Materials for Biological Applications 60: 348-356. 10） Zhang, Y., Y. Sun, et al. (2010). "Synthesis, Biodistribution, and Microsingle Photon Emission Computed Tomography (SPECT) Imaging Study of Technetium-99m Labeled PEGylated Dendrimer Poly(amidoamine) (PAMAM)-Folic Acid Conjugates." Journal of Medicinal Chemistry 53(8): 3262-3272.

3. 毕业设计（论文）进程安排

2018.1.2-2018.1.19 文献查询和资料阅读 2018.1.19-2018.1.23 研究方案制定和开题报告写作 2018.1.24-2018.3.10 实践内容的准备 2018.3.11-2018.5.10 实践 2018.5.10-2018.5.15 实践内容处理与结果分析 2018.5.16-2018.6.1 毕业论文书写