Abstract

The therapeutic effect of traditional anti-tumor drugs is not ideal. The drugs tend to act on healthy human tissues before they reach the tumor growth area, causing harm to the human body. The drug carrier can wrap the drug and prevent the drug from being released in healthy human tissues, which can not only improve the therapeutic effect of the drug, but also reduce the cytotoxicity. The dendrimer is a macromolecule with a three-dimensional tree structure. Peptide dendrimers are easily accepted by organisms and can be degraded into harmless substances in organisms. Among them, peptides synthesized from natural amino acids are widely used. The combination of drugs and peptide dendrimers with environmentally sensitive chemical bonds to change the environmental conditions (pH, temperature, etc.) to achieve drug release can increase drug specificity.

This subject will design a peptide-based nano drug-loading system that uses lysine with different amino protecting groups as raw materials to obtain dendrimers. Antitumor drugs are loaded on dendrimers through pH-sensitive hydrazone bonds to make them into Controlled drug release system with pH response. The expectation of this drug-loading system is that the size is about 100 nanometers and the structure is regular; it can be stable in the blood circulation system for a long time and will not be discharged; it can stay in the tumor growth area and quickly release the drug carried.

Keywords Nano-drug carrier；Dendrimer；Environmental response；Drug controlled release