论文总字数：17731字

摘 要

胆舒胶囊（英文名称Synopsis）为利胆药物剂型胶囊:50mg/粒.胆舒胶囊为胶囊剂，具有特殊气味，味辛凉，经试验反应，该胶囊具有利胆、止痛和消炎的作用，能溶解体内的胆固醇类结石等。经多次临床验证表明，对慢性结石性胆囊炎，有效率高达为92%。止痛效果好，生效快。

本设计为年产5亿粒胆舒胶囊生产车间工艺设计，按照课程设计的要求和有关规定，本设计包括工艺概述、工艺流程、物料衡算、工艺设备选择、车间工艺布置、洁净区设置、三废处理等。

关键词：胆舒胶囊 车间工艺 设计

Abstract

Danshu capsules (English name Synopsis) is Lidan capsule: 50mg/ particles. Drug formulations of Danshu capsule capsule, has a special smell, pungent and cool, the test reaction, the capsule has choleretic, analgesic and anti-inflammatory effect, can dissolve cholesterol gallstones. After a number of clinical trials showed that, for chronic calculous cholecystitis, the effective rate was as high as 92%. Analgesic effect is good, fast.

The design for the annual output of 500 million grains of Danshu capsule production workshop design, in accordance with the requirements of the curriculum design and the relevant provisions of this design includes the overview of the process, process, material balance, process equipment selection, shop layout, clean area, waste treatment etc..

Key words: Danshu capsule factory process design

目录

1. 前言.....................................................................1

1.1 研究背景与意义.....................................................1

1.2 调研报告...........................................................1

1. 工艺概述.................................................................3

2.1 胶囊概述...........................................................3

2.2 设计目的...........................................................3

2.3 设计原则...........................................................3

2.4 设计要求...........................................................4

1. 工艺流程设计.............................................................5

3.1 产品类型与生产规模.................................................5

3.2 包装形式...........................................................5

3.3 生产工艺...........................................................5

1. 物料衡算.................................................................7

4.1 药物颗粒质量计算...................................................7

4.2 包装材料计算.......................................................7

1. 工艺设备选型说明.........................................................8

5.1 生产设备选型说明 ..................................................8

5.2 选型原则...........................................................8

5.3 设备的主要参数选择.................................................8

5.4 设备的可靠性与维修性...............................................9

5.5 制药企业设备选型...................................................9

5.6 设备选择...........................................................9

5.6.1 粉碎设备.....................................................10

5.6.2 筛分设备.....................................................10

5.6.3 湿法制粒机...................................................10

5.6.4 卧式沸腾干燥机...............................................10

5.6.5 整粒机.......................................................11

5.6.6 混合机.......................................................11

5.6.7 胶囊填充机...................................................11

5.6.8 胶囊抛光机...................................................11

5.6.9 铝塑包装机...................................................11

5.6.10 工艺设备一览表..............................................12

1. 车间工艺平面布置说明.....................................................13

6.1 车间布置主要依据求.................................................13

6.2 车间布置平面图.....................................................13

6.3 车间产尘的处理.....................................................13

6.4 车间排热、排湿及臭味的处理.........................................13

6.5 参观走廊的设置.....................................................13

6.6 安全门的设置.......................................................14

1. 洁净区的设置.............................................................15

7.1 车间净化措施.......................................................15

7.1.1 水的净化.....................................................15

7.1.2 人的净化.....................................................15

7.1.3 物料的净化...................................................15

7.1.4 设备器具的净化...............................................16

1. “三废” 的处理..........................................................17

8.1 废水的处理.........................................................17

8.2 废气的处理.........................................................17

8.3 废渣的处理.........................................................17

1. 总结.....................................................................18
2. 致谢....................................................................19
3. 参考文献................................................................20

12.附录....................................................................21

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