1. 毕业设计（论文）的内容和要求

1. 理解抑郁症、血脑屏障相关概念以及材料跨血脑屏障的途径，明确其研究进展； 2. 熟悉可跨血脑屏障生物材料的分类、特性； 3. 了解可跨血脑屏障生物材料应用于治疗抑郁症的优势和缺陷； 4. 掌握基于肽类树形分子制备靶向性跨血脑屏障材料的基本方法以及表征手段。

2. 参考文献

1. Abbott, N. J.; Ronnback, L.; Hansson, E., Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006, 7 (1), 41-53. 2. Banks, W. A., From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery. Nat Rev Drug Discov 2016, 15 (4), 275-92. 3. Chen, Y.; Liu, L., Modern methods for delivery of drugs across the blood-brain barrier. Adv Drug Deliv Rev 2012, 64 (7), 640-65. 4. Clark, A. J.; Davis, M. E., Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core. Proc Natl Acad Sci U S A 2015, 112 (40), 12486-91. 5. Fang, F.; Zou, D.; Wang, W.; Yin, Y.; Yin, T.; Hao, S.; Wang, B.; Wang, G.; Wang, Y., Non-invasive approaches for drug delivery to the brain based on the receptor mediated transport. Mater Sci Eng C Mater Biol Appl 2017, 76, 1316-1327. 6. Furtado, D.; Bjornmalm, M.; Ayton, S.; Bush, A. I.; Kempe, K.; Caruso, F., Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases. Adv Mater 2018, 30 (46), e1801362. 7. Otte, C.; Gold, S. M.; Penninx, B. W.; Pariante, C. M.; Etkin, A.; Fava, M.; Mohr, D. C.; Schatzberg, A. F., Major depressive disorder. Nat Rev Dis Primers 2016, 2, 16065.

3. 毕业设计（论文）进程安排

2018.12-2019.01进行文献调研，确定研究方案，完成开题报告。

2019.02-2018.04 开展实验研究，完成可跨血脑屏障生物材料的制备及相关表征。

2019.05-2019.06 进行数据汇总、整理、分析，完成毕业论文撰写和答辩相关材料准备工作。