1. 毕业设计（论文）的内容和要求

海藻酸钙(calculate-sodium alginate, ca-sa)基胶囊是能够将活性物质等芯材包覆于囊芯的优良固定化体系，具有较大的空腔，能为囊芯提供固定化空间，同时囊膜对囊芯具有一定的阻隔作用，可减少芯层物质的泄漏、延缓药释放等，已广泛应用于生物化工、药妆、食品等各领域。

目前，ca-sa基胶囊存在的主要问题之一是，非水环境下储存时，胶囊极易失水塌陷，缩短了胶囊的使用寿命。

本课题拟通过静电喷雾法改进ca-sa基胶囊的制备工艺，确定胶囊的最佳制备条件，并通过β-环糊精(β-cydodextrin, β-cd)对胶囊囊壁改性，降低胶囊失重率，延长其使用期。

2. 参考文献

[1] Connors K A. The stability of cyclodextrin complexes in solution[J]. Chem Rev, 1997, 97:1325-1357. [2] Uekama K, Hirayama F, Irie T. Cyclodextrin drug carrier systems[J]. Chem Rev, 1998, 98:2045-2076. [3] Manakker F, Vermonden T, Nostrum C F, et al. Cyclodextrin-based polymeric materials: synthesis, properties and pharmaceutical/biomedical applications[J]. Biomacromolecules, 2009, 10: 3157-3175. [4] Loftsson T, Brewster M E. Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization[J]. Journal of Pharmaceutical Sciences, 1997, 85: 1017-1025. [5] Davis M E, Brewster M E. Cyclodextrin-based pharmaceutics, past present and future[J]. Nature Reviews: Drug Discovery, 2004, 3: 1023-1035. [6] Vyas A, Saraf S, Saraf S. Cyclodextrin-based novel drug delivery systems[J]. J Incl Phenom Macrocycl Chem, 2008, 62: 23-42. [7] Messner M, Kurkov S V, Jansook P, et al. Self-assembled cyclodextrin aggregates and nanoparticles[J]. International Journal of Pharmaceutics, 2010, 387: 199-208. [8] 周应学,范晓东,任杰,等.环糊精-药物复合纳米粒子的制备及其控制释放研究进展[J].材料导报,2010,24:136-140. [9] Combotz W R, Wee S F. Protein Release from Alginate Matrics[J]. Advanced Drug Delivery Reviews, 1998, 31: 267-285. [10] Lee Hyun-Ho, Park Oh-Jin. Continuous Production of Uniform Calcium Alginate Beads by Sound Wave Induced Vibration[J]. Journal of Chemical Technology Biotechnology, 1996, 67: 255-259. [11] Olav Gaserd, Aadrea Sannes. Microcapsules of Alginate-Chitosan. II. A Study of Capsule Stability and Permeability[J]. Biomaterials, 1999, 20: 774. [12] Huang Keng-shang, Liu Ming-kai, Wu Chun-han, et al. Calcium Alginate Microcapsule Generation on a Microfluidic System Fabricated Using the Optical Disk Process[J]. Journal of Micromechanics and Microengineering, 2007, 17(8): 1428-1430. [13] 柴炎炎,梅乐和,姚善泾.液芯CMC-ALG微胶囊的制备、扩散性能及初步应用研究[J].膜科学与技术,2004,24(3):10-14. [14] Tanriseven A , Dogan S.Immobilization of invert ase w ithin calcium alginat e gel capsules[J]. Process Biochmistry, 2001 , 36(11): 1081-1083. [15] 范宏斌,胡蕴云,吴红,等.转化生长因子明胶微球制备及体外缓释研究[J].中国矫形外科杂志,2005,13(3):208-211. [16] 高建成.高压静电法制备蛋白类药物微胶囊的研究[D].上海:上海理工大学, 2004. [17] Toso C, Oberholze R J, Ceausog Lu I, et al. Intraportalinjection of 400μm microcapsules in a large-animal model[J]. T ranspl Int, 2003, 16: 405-410. [18] 李保国,华泽钊,刘占杰.高压静电场制备微胶囊的研究[J].上海理工大学学报,2000,22(3):189-193. [19] 张武杰,李保国,张超,等.静电喷雾法制备海藻酸钙-羧甲基纤维素钠液芯微胶囊的工艺选优[J].上海理工大学学报,2007,04(29):350-352.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 11.28-12.02 与学生见面，布置任务，对论文说明 12.05-12.16 查阅资料 12.19-12.23 文献综述，撰写开题报告 12.26-12.30 实验准备工作 01.02-06.02 进行毕业论文相关实验 06.05-06.16 论文撰写、修改 06.19-06.23 论文撰写、修改，论文答辩