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毕业论文网 > 任务书 > 化学化工与生命科学类 > 应用化学 > 正文

藻油脂肪酸-阿霉素脂质体的制备任务书

 2020-05-01 08:39:36  

1. 毕业设计(论文)的内容和要求

癌症是全球死亡的主要原因之一,迫切需要先进的治疗技术。

新型纳米材料和纳米载体的开发已经为改善癌症中的药物递送提供了主要驱动力。

大多数纳米载体应用的主要目的是保护药物在全身递送后免于被快速降解,并允许其以达到治疗浓度到达肿瘤部位,同时尽可能避免药物递送至正常部位以减少不利影响。

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2. 参考文献

[1]Lasic, D. D.; Application of liposomes. In Handbook of Biological Physics, Lipowsky, R., Sackmann, E., Eds.; Elsevier: Amsterdam, 1993; Vol.l, pp 493. [2] 苑再武. 囊泡的形成、结构及有序结构转变研究[D]. 山东大学, 2006. [3] 周文婷. 表面活性剂囊泡形成的机理研究[D]. 厦门大学, 2007. [4] Tung S H, Lee H Y, Raghavan S R. A Facile Route for Creating ”Reverse” Vesicles: Insights into ”Reverse” Self-Assembly in Organic Liquids[J]. Journal of the American Chemical Society, 2008, 130(27):8813-7. [5] Lee J H. SOFT MATERIALS BASED ON VESICLES AND BIOPOLYMERS[J]. 2006. [6] Lian T, Ho R J. Trends and developments in liposome drug delivery systems.[J]. Journal of Pharmaceutical Sciences, 2001, 90(6):667-80. [7] Lukyanov A N, Elbayoumi T A, Chakilam A R, et al. Tumor-targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody.[J]. Journal of Controlled Release, 2004, 100(1):135-44. [8] Mao M, Huang J, Buyao Zhu A, et al. The Transition from Vesicles to Micelles Induced by Octane in Aqueous Surfactant Two-Phase Systems[J]. Journal of Physical Chemistry B, 2001, 106(1):219-225. [9] Yin H, Lin Y, Huang J, et al. Temperature-induced vesicle aggregation in catanionic surfactant systems: the effects of the headgroup and counterion.[J]. Langmuir the Acs Journal of Surfaces Colloids, 2007, 23(8):4225-4230. [10] Uchegbu I F, Vyas S P. Non-ionic surfactant based vesicles (niosomes) in drug delivery[J]. International Journal of Pharmaceutics, 1998, 172(1#8211;2):33-70. [11] Mehta S K, Jindal N, Kaur G. Quantitative investigation, stability and in vitro release studies of anti-TB drugs in Triton niosomes.[J]. Colloids Surfaces B Biointerfaces, 2011, 87(1):173-179. [12] Discher D E, Eisenberg A. Polymer Vesicles[J]. Science, 2002, 297(5583):967-73. [13] Wang F, Wang Y C, Yan L F, et al. Biodegradable vesicular nanocarriers based on poly(#603;-caprolactone)- block -poly(ethyl ethylene phosphate) for drug delivery[J]. Polymer, 2009, 50(21):5048-5054. [14] Kai Liu, Chao Wang, Prof. Zhibo Li,等. Superamphiphiles Based on Directional Charge-Transfer Interactions: From Supramolecular Engineering to Well-Defined Nanostructures #8224;[J]. Angewandte Chemie International Edition, 2011, 50(21):4952-6. [15] Zhang X, Wang C. Supramolecular amphiphiles[J]. Chemical Society Reviews, 2011, 40(1):94-101. [16] Hassan N, Ruso J M, Pintilde;eiro Aacute;. Hydrogenated/fluorinated catanionic surfactants as potential templates for nanostructure design.[J]. Langmuir, 2011, 27(16):9719-28. [17] Xu D, Cheng Q. Surface-bound lipid vesicles encapsulating redox species for amperometric biosensing of pore-forming bacterial toxins.[J]. Journal of the American Chemical Society, 2002, 124(48):14314-5. [18] Egli S, Nussbaumer M G, Balasubramanian V, et al. Biocompatible functionalization of polymersome surfaces: a new approach to surface immobilization and cell targeting using polymersomes.[J]. Journal of the American Chemical Society, 2011, 133(12):4476-83. [19] Allen T M, Cullis P R. Drug Delivery Systems: Entering the Mainstream[J]. Science, 2004, 303(5665):1818-22. [20] Boudier A, Castagnos P, Soussan E, et al. Polyvalent catanionic vesicles: exploring the drug delivery mechanisms.[J]. International Journal of Pharmaceutics, 2011, 403(1-2):230-6. [21] Kaler E W, Zasadzinski J A N. Spontaneous vesicle formation in aqueous mixtures of single-tailed surfactants.[J]. Science, 1989, 245(4924):1371-4. [22] 余娜, 任殿福, 刘春丽,等. 阴阳离子表面活性剂复配自发形成囊泡的研究[J]. 吉林大学学报理学版, 2007, 45(4):652-656. [23] Wang X, Danoff E J, Sinkov N A, et al. Highly Efficient Capture and Long-Term Encapsulation of Dye by Catanionic Surfactant Vesicles[J]. Langmuir, 2006, 22(15):6461-4. [24] Consola S, Blanzat M, Perez E, et al. Design of original bioactive formulations based on sugar-surfactant/non-steroidal anti-inflammatory catanionic self-assemblies: a new way of dermal drug delivery.[J]. Chemistry - A European Journal, 2007, 13(11):3039-47.

3. 毕业设计(论文)进程安排

2018.12.1-12.5 与导师会面,布置论文题目及要求 12.6-12.21 申报毕业设计题目,下达任务书,做好开题前期工作 12.22-2018.1.18 完成外文翻译、文献综述和开题报告 1.19-3.1 离子对合成,脂质体系形成 3.2-4.30 材料结构及性质的表征 4.31-5.31 数据整理,书写论文,制作PPT 6.1-6.10 准备论文答辩

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