1. 毕业设计（论文）的内容和要求

1.文献查阅 从查阅文献着手，在中国期刊网，维普数据库，超星数字图书馆，美国化学学会(acs)数据库，ca，sci等检索资源上查阅有关海因合成与酸碱共催化催化开环聚合的相关文献。

2．文献阅读及综述 阅读与课题相关的文献，了解海因与开环聚合的基本情况、方法和国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

1. Konnert, L.; Lamaty, F.; Martinez, J.; Colacino, E., Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold. Chem Rev 2017, 117 (23), 13757-13809. 2. Izquierdo, J.; Etxabe, J.; Dunabeitia, E.; Landa, A.; Oiarbide, M.; Palomo, C., Enantioselective Synthesis of 5,5-Disubstituted Hydantoins by Bronsted Base/H-Bond Catalyst Assisted Michael Reactions of a Design Template. Chemistry 2018, 24 (28), 7217-7227. 3. Konnert, L.; Reneaud, B.; de Figueiredo, R. M.; Campagne, J. M.; Lamaty, F.; Martinez, J.; Colacino, E., Mechanochemical preparation of hydantoins from amino esters: application to the synthesis of the antiepileptic drug phenytoin. The Journal of organic chemistry 2014, 79 (21), 10132-42. 4. McCann, B. W.; Song, H.; Kocer, H. B.; Cerkez, I.; Acevedo, O.; Worley, S. D., Inter- and intramolecular mechanisms for chlorine rearrangements in trimethyl-substituted N-chlorohydantoins. The journal of physical chemistry. A 2012, 116 (26), 7245-52. 5. Liu, H.; Yang, Z.; Pan, Z., Synthesis of highly substituted imidazolidine-2,4-dione (hydantoin) through Tf2O-mediated dual activation of Boc-protected dipeptidyl compounds. Organic letters 2014, 16 (22), 5902-5. 6. Demartin, F.; Devillanova, F. A.; Diaz, A.; Isaia, F.; Lippolis, V.; Verani, G., 13c Nmr, Hose Calculations and Structural Analyses of 3,5,5-Trimethyl-4-Oxoimidazolidine-2-Thione and -4-Thioxoimidazolidine-2-One. Phosphorus, Sulfur, and Silicon and the Related Elements 1992, 70 (1), 121-130. 7. Gill, M.; Tanwar, D.; Ratan, A., Facile One-Pot Synthesis of Substituted Hydantoins from Carbamates. Synlett 2017, 28 (17), 2285-2290. 8. Hedrick, R. M. W. a. J. L., Thiourea-Based Bifunctional Organocatalysis: Supramolecular Recognition for Living Polymerization. Journal of the American Chemical Society 2005. 9. Lin, B.; Waymouth, R. M., Urea Anions: Simple, Fast, and Selective Catalysts for Ring-Opening Polymerizations. Journal of the American Chemical Society 2017, 139 (4), 1645-1652. 10. Naumann, S.; Scholten, P. B.; Wilson, J. A.; Dove, A. P., Dual Catalysis for Selective Ring-Opening Polymerization of Lactones: Evolution toward Simplicity. Journal of the American Chemical Society 2015, 137 (45), 14439-45. 11. Kazakov, O. I.; Kiesewetter, M. K., Cocatalyst Binding Effects in Organocatalytic Ring-Opening Polymerization of l-Lactide. Macromolecules 2015, 48 (17), 6121-6126.

3. 毕业设计（论文）进程安排

2018.12.25-2019.01.04 熟悉反应原理和实验操作，查阅文献，确定课题，撰写任务书 2019.01.05-2019.03.04 确定实验方案，对课题进行初步实验，完成开题报告 2019.03.05-2019.03.10 对前一阶段研究内容进行中期汇报，完成中期自检，确定下一步实验方案 2019.03.11-2019.03.15 扩展课题研究范围，改进实验方案，对数据整理分析，撰写论文 2019.03.16-2019.05.15 完善毕业论文，补充数据，定稿