1. 毕业设计（论文）的内容和要求

1.熟悉基本的实验操作，理解实验的基本内容；2.能做到流利阅读文献，掌握文献内容；3.熟悉运用各种信息平台查阅相关信息；4.了解当下化学方向中合成1，4-二羰基化合物的内容，了解背景和意义；5.熟悉并掌握环丙烯开环反应。

2. 参考文献

(1) Meiyan Ni,Jianguo Zhang,Xiaoyu Liang,Yaojia Jiang and Teck-Peng Loh, Directed C#8211;C bond cleavage of a cyclopropane intermediate generated from N-tosylhydrazones and stable enaminones: expedient synthesis of functionalized 1,4-ketoaldehydes.Chem. Commun., 2017, 53, 12286-12289. (2) Erica J. Carrier, Irene Zagol-Ikapitte, Venkataraman Amarnath, Olivier Boutaud and John A. Oates, Levuglandin Forms Adducts with Histone H4 in a Cyclooxygenase-2-Dependent Manner, Altering Its Interaction with DNA. Biochemistry, 2014, 53, 2436-2441. (3) S. Roscales and A. G. Csa′ky#168;, Transition-metal free reactions of boronic acids: cascade addition #8211; ring-opening of furans towards functionalized γ-ketoaldehydes, Chem. Commun., 2016, 52, 3018-3021. (4) Ryan A. Shenvi and E. J. Corey, A Short and Efficient Synthesis of (-)-7-Methylomuralide, a Potent Proteasome Inhibitor. J. Am. Chem. Soc., 2009, 131, 5746#8211;5747. (5) E. J. Corey, Angel Guzman-Perez, and Teck-Peng Loh, Demonstration of the Synthetic Power of Oxazaborolidine-Catalyzed Enantioselective Diels-Alder Reactions by Very Efficient Routes to Cassiol and Gibberellic Acid. J. Am. Chem. Soc., 1994, 116, 3611#8211;3612. (6) Zhuo Tang, Zhi-Hua Yang, Xiao-Hua Chen, Lin-Feng Cun, Ai-Qiao Mi, Yao-Zhong Jiang, and Liu-Zhu Gong ,A Highly Efficient Organocatalyst for Direct Aldol Reactions of Ketones with Aldedydes. J. Am. Chem. Soc., 2005, 127, 9285#8211;9289. (7) Manabu Hatano, Shinji Suzuki, and Kazuaki Ishihara, Highly Efficient Alkylation to Ketones and Aldimines with Grignard Reagents Catalyzed by Zinc(II) Chloride. J. Am. Chem. Soc., 2006, 128, 9998#8211;9999. (8) Irene Zagol-Ikapitte, Venkataraman Amarnath, Manju Bala, L. Jackson Roberts II,, John A. Oates, and Olivier Boutaud, Characterization of Scavengers of γ-Ketoaldehydes That Do Not Inhibit Prostaglandin Biosynthesis. Chem. Res. Toxicol., 2010, 23, 240#8211;250. (9) Masakazu Sono, Yasuyo Nakashiba, Katsuyuki Nakashima, and Motoo Tori, Cyclization into Hydrindanones Using Samarium Diiodide. J. Org. Chem., 2000, 65, 3099#8211;3106. (10) Xiaomin Xie and Shannon S. Stahl, Efficient and Selective Cu/Nitroxyl-Catalyzed Methods for Aerobic. J. Am. Chem. Soc., 2015, 137, 3767#8211;3770.

3. 毕业设计（论文）进程安排

2019.3.1-2019.3.4 进入实验室，交代相关事宜，安排实验任务 2019.3.4 查阅文献，准备开题报告 2019.3.10-2019.3.31 合成实验所需原料 2019.4.1-2019.5.29 选择相应催化剂催化反应进行，筛选反应条件，优化条件 2019.5.30-2019.6.4 实验数据整理分析 2019.6.4-2019.6.10 撰写论文 2019.6.10-2019.6.15 论文答辩