1. 毕业设计（论文）的内容和要求

通过化工流程模拟软件建立反应精馏模型，利用新型智能算法对反应精馏过程中的各个连续变量以及离散变量进行优化。

由于智能算法的高效性以及鲁捧性，将其应用于反应精馏过程的全局优化具有非常广阔的前景。

2. 参考文献

[1]. Cardoso, M.F., et al., Optimization of reactive distillation processes with simulated annealing. Chemical Engineering Science, 2000. 55(21): p. 5059-5078. [2]. Pouml;pken, T., L. Gouml;tze and J. Gmehling, Reaction Kinetics and Chemical Equilibrium of Homogeneously and Heterogeneously Catalyzed Acetic Acid Esterification with Methanol and Methyl Acetate Hydrolysis. Industrial amp; Engineering Chemistry Research, 2000. 39(7): p. 2601-2611. [3]. Jackson, J.R. and I.E. Grossmann, A disjunctive programming approach for the optimal design of reactive distillation columns. Computers amp; Chemical Engineering, 2001. 25(11#8211;12): p. 1661-1673. [4]. Cheng, J., et al., Optimal steady-state design of reactive distillation processes using simulated annealing. Journal of the Taiwan Institute of Chemical Engineers, 2009. 40(2): p. 188-196. [5]. Harwardt, A., et al., Conceptual Design of a Butyl-levulinate Reactive Distillation Process by Incremental Refinement. Chinese Journal of Chemical Engineering, 2011. 19(3): p. 371-379. [6]. Miranda-Galindo, E.Y., et al., Reactive Thermally Coupled Distillation Sequences: Pareto Front. Industrial amp; Engineering Chemistry Research, 2011. 50(2): p. 926-938. [7]. V#225;zquez-Ojeda, M., et al., Optimization and Controllability Analysis of Thermally Coupled Reactive Distillation Arrangements with Minimum Use of Reboilers. Industrial amp; Engineering Chemistry Research, 2012. 51(17): p. 5856-5865. [8]. Amte, V., et al., Optimization based conceptual design of reactive distillation for selectivity engineering. Computers amp; Chemical Engineering, 2013. 48: p. 209-217. [9]. Domingues, L., C.I.C. Pinheiro and N.M.C. Oliveira, Optimal design of reactive distillation systems: Application to the production of ethyl tert-butyl ether (ETBE). Computers amp; Chemical Engineering, 2014. 64: p. 81-94. [10]. Segovia-Hern#225;ndez, J.G., S. Hern#225;ndez and A. Bonilla Petriciolet, Reactive distillation: A review of optimal design using deterministic and stochastic techniques. Chemical Engineering and Processing: Process Intensification, 2015. 97: p. 134-143. [11]. Huang, F., et al., Innovative Ethylene Glycol Diacetate synthesis process in a single reactive distillation column. Chemical Engineering and Processing: Process Intensification, 2016. 109: p. 80-89. [12]. Lee, S. and I.E. Grossmann, A global optimization algorithm for nonconvex generalized disjunctive programming and applications to process systems. Computers amp; Chemical Engineering, 2001. 25(11#8211;12): p. 1675-1697. [13]. Burri, J.F. and V.I. Manousiouthakis, Global optimization of reactive distillation networks using IDEAS. Computers amp; Chemical Engineering, 2004. 28(12): p. 2509-2521. [14]. 李枝勇, 蝙蝠算法及其在函数优化中的应用研究, 2013, 上海理工大学. 第 93页. [15]. 盛孟龙, 贺兴时与王慧敏, 一种改进的自适应变异蝙蝠算法. 计算机技术与发展, 2014(10): 第131-134页. [16]. 李煜与马良, 新型全局优化蝙蝠算法. 计算机科学, 2013(09): 第225-229页.

3. 毕业设计（论文）进程安排

2月20日～3月10日：查阅文献，翻译外文文献，完成开题报告； 3月11日～4月10日：进行反应精馏过程模拟，并利用Matlab软件进行算法编写，并将两者相链接。

4月11日～5月10日：对算法相关参数进行优化，并对算法进行合理改进； 5月11日～5月25日：完善各部分工作，撰写毕业论文报告； 5月26日～6月15日：修改论文，准备答辩。