1. 毕业设计（论文）的内容和要求

内容：一种基于聚多巴胺量子点的亚硫酸根探针的设计合成及其在食物中亚硫酸盐检测的应用 要求：设计的纳米荧光探针能够高灵敏度和选择性识别的亚硫酸根。

此外,该荧光探针能够成功地应用于确定亚硫酸根在食品中的含量。

2. 参考文献

[1] J.H. Kim, S.M. Bae, M.H. Na, H. Shin, Y.J. Yang, K.H. Min, K.Y. Choi, K. Kim, R.W. Park, I.C. Kwon, B.H. Lee, A.S. Hoffman, I.S. Kim, Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues, J. Controlled Release. 157 (2012) 493-499. [2] J. Yao, M. Yang, Y. Duan, Chemistry, biology, and medicine of fluorescent nanomaterials and related systems: new insights into biosensing, bioimaging, genomics, diagnostics, and therapy, Chem. Rev. 114 (2014) 6130-6178. [3] X. L. Feng, F.T. Lv, L.B. Liu, H.W. Tang, C.F. Xing, Q. Yang, S. Wang, Noninvasive visualization of in vivo drug delivery of poly(l-glutamic acid) using contrast-enhanced MRI, ACS Appl. Mater. Interfaces. 2 (2010) 2429-2435. [4] H. Niu, Y.Q. Yang, H.Q. Zhang, Efficient one-pot synthesis of hydrophilic and fluorescent molecularly imprinted polymer nanoparticles for direct drug quantification in real biological samples, Biosens. Bioelectron.74 (2015) 440-446. [5] A. Postma, Y. Yan, Y. Wang, A.N. Zelikin, E. Tjipto, F. Caruso, Self-polymerization of dopamine as a versatile and robust technique to prepare polymer capsules, Chem. Mater. 21 (2009) 3042-3044. [6] A. Postma, Y. Yan, Y. Wang, A.N. Zelikin, E. Tjipto, F. Caruso, Self-polymerization of dopamine as a versatile and robust technique to prepare polymer capsules, Chem. Mater. 21 (2009) 3042-3044. [7] X. Zhang, S. Wang, L. Xu, L. Feng, Y. Ji, L. Tao, S. Li, Y. Wei, Biocompatible polydopamine fluorescent organic nanoparticles: facile preparation and cell imaging, Nanoscale. 4 (2012) 5581-5584. [8] J.H. Lin, C.J. Yu, Y.C. Yang, W.L. Tseng, Formation of fluorescent polydopamine dots from hydroxyl radical-induced degradation of polydopamine nanoparticles, Phys. Chem. Chem. Phys. 17 (2015) 15124-15130. [9] T. Gao, X.Z. Cao, P. Ge, J. Dong, S.Q. Yang, H. Xu, Y. Wu, F. Gao, W.B. Zeng, A self-assembled fluorescent organic nanoprobe and its application for sulfite detection in food samples and living systems, Org. Biomol. Chem. 15 (2017) 4375-4382. [10] A.K. Liu, R.X. Ji, S.L. Shen, X.Q. Cao, Y.Q. Ge, A ratiometric fluorescent probe for sensing sulfite based on a pyrido[1,2-a]benzimidazole fluorophore, New J. Chem. 41 (2017) 10096--10100.

3. 毕业设计（论文）进程安排

2017.04-2017.09： 聚多巴胺量子点纳米探针的合成、表征，和亚硫酸根选择性检验； 2017.10-2018.02： 将合成的探针应用于确定亚硫酸根在食品中的含量； 2018.03-2018.05： 总结结果、撰写毕业论文。