1. 毕业设计（论文）的内容和要求

在过去的十年中，n-杂环卡宾（nhc）已被证明是最强大的有机催化剂之一，并且已经能够构建一系列杂环化合物。

另一方面，由于硅原子具有特殊的物理和电子性质，使得手性有机硅烷受到越来越多的关注。

手性有机硅烷在有机合成、材料科学、农业科学和医药化学中获得了较为广泛的应用。

2. 参考文献

[1] Matthew N. Hopkinson, Christian Richter, Michael Schedler,Frank Glorius.An overview of N-heterocyclic carbenes[J].Nature,2014,510: 485#8211;496. [2] Dieter Enders,Oliver Niemeier,Alexander Henseler.Organocatalysis by N-Heterocyclic Carbenes[J].Chemical Reviews, 2007, 107: 5606#8722;5655. [3] Darrin M. Flanigan,Fedor Romanov-Michailidis,Nicholas A. White,Tomislav Rovis. Organocatalytic Reactions Enabled by N#8209;Heterocyclic Carbenes[J].Chemical Reviews,2015,115(17): 9307-9387. [4] Gribble Jr M W, Pirnot M T, Bandar J S, et al. Asymmetric copper hydride-catalyzed Markovnikov hydrosilylation of vinylarenes and vinyl heterocycles[J]. Journal of the American Chemical Society, 2017, 139(6): 2192-2195. [5] Chen D, Zhu D X, Xu M H. Rhodium (I)-catalyzed highly enantioselective insertion of carbenoid into Si#8211;H: Efficient access to functional chiral silanes[J]. Journal of the American Chemical Society, 2016, 138(5): 1498-1501. [6] Shintani R, Ichikawa Y, Hayashi T, et al. Catalytic asymmetric synthesis of allylsilanes through rhodium/chiral diene-catalyzed 1, 4-addition of alkenyl [2-(hydroxymethyl) phenyl] dimethylsilanes[J]. Organic Letters, 2007, 9(22): 4643-4645. [7] Kitanosono T, Zhu L, Liu C, et al. An insoluble copper (II) acetylacetonate#8211;chiral bipyridine complex that catalyzes asymmetric silyl conjugate addition in water[J]. Journal of the American Chemical Society, 2015, 137(49): 15422-15425. [8] Meng W, Feng X, Du H. Frustrated Lewis pairs catalyzed asymmetric metal-free hydrogenations and hydrosilylations[J]. Accounts of chemical research, 2017, 51(1): 191-201

3. 毕业设计（论文）进程安排

19.01.11~19.02.20 文献调研 19.02.20~19.05.10 外文翻译，开题报告，开展实验工作 19.05.10~19.05.28 中后期实验阶段及数据收集 19.05.28~19.06.10 数据整理，撰写论文