1. 毕业设计（论文）的内容和要求

癌症（恶性肿瘤）作为全球致死率最高的疾病之一，其高发病率与高死亡率促进了癌症治疗方式的进步。

光治疗，包含光热治疗和光动力治疗，作为新兴的肿瘤治疗方式，因其低毒、无抗药性、无侵入性和高靶向性等特点，受到研究者们广泛关注。

但ptt和pdt在临床应用上都面临相应的障碍。

2. 参考文献

1. Y LIU, Y JIANG, M ZHANG, et al. Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment of Solid Tumors. Accounts of chemical research, 2018, 51(10): 2502-2511. 2. Y CAI, W SI, W HUANG, et al. Organic Dye Based Nanoparticles for Cancer Phototheranostics. Small, 2018, 14(25): 1704247. 3. Q Y TANG, W Y XIAO, C H HUANG, et al. pH-Triggered and Enhanced Simultaneous Photodynamic and Photothermal Therapy Guided by Photoacoustic and Photothermal Imaging. Chemistry of Materials, 2017, 29(12): 5216-5224. 4. Q Q MIAO, C XIE, X ZHEN, et al. Molecular Afterglow Imaging with Bright, Biodegradable Polymer Nanoparticles. Nature Biotechnology, 2017, 35(11): 1102-1110. 5. X LI, S KOLEMEN, J YOON, et al. Activatable Photosensitizers: Agents for Selective Photodynamic Therapy. Advanced Functional Materials, 2017, 27(5): 1604053. 6. L Cheng, K Yang, Q Chen, Organic Stealth Nanoparticles for Highly Effective in Vivo Near-Infrared Photothermal Therapy of Cancer[J]. Acs Nano, 2012, (6):5605 -5613 7. X L Cai, J Liu, W H Liew, et al. Organic Molecules with Propeller Structures for Efficient Photoacoustic Imaging and Photothermal Ablation of Cancer cells. Mater Chem Front, 2017, (8):1556 - 1562. 8. S L Luo, E L Zhang, Y P Su, et al. A review of NIR Dyes in Cancer Targeting and Imaging. Biomaterials, 2011, (32):7127 - 7138. 9. X J Song, Q Chen, Z Liu. Recent Advances in the Development of Organic Photothermal Nano-Agents. Nano Research，2015，(8):340 -354. 10. H J Zhu, P H Cheng, P Chen, et al. Recent Progress in the Development of Near-Infrared Organic Photothermal and Photodynamic Nanotherapeutics. Biomaterials Sci, 2018, (6):746 - 765. 11. A L Antaris, H Chen, K Cheng, et al. A Small-Molecule Dye for NIR-II Imaging. Nature Mater, 2016, (15):235 - 243. 12. Y Sun, C R Qu, H Chen, et al. Novel Benzo-Bis(1,2,5-thiadiazole) Fluorophores for in Vivo NIR-II Imaging of Cancer. Chem Sci，2016，(16)：6203 ~ 6207. 13. D L Sheng, T Z Liu, L M Deng, et al. Perfluorooctyl Bromide Indocyanine Green Co-loaded Nanoliposomes for Enhanced Multimodal Imaging-Guided Phototherapy. Biomaterial, 2018, (165):1 - 13. 14. B H Li, L F Lu, M Y Zhao, et al. Deep-Tissue High-Resolution Dynamic Bioimaging. Angew Chem Int Ed, 2018, (57):1 - 6. 15. J Qi, Y Fang, R T K Kwok, et al. Highly Stable Organic Small Molecular Nanoparticles as an Advanced and Biocompatible Phototheranostic Agent of Tumor in Living Mice. ACS Nano, 2017, (11):7177 - 7188.

3. 毕业设计（论文）进程安排

每周六天，每天8-10小时。

1、第1-4周：文献阅读，了解相关领域的研究动态，课题背景；学习实验室安全知识。

2、第5-8周：学习实验室安全知识；进入实验室学习。