1. 毕业设计（论文）的内容和要求

树状大分子药物递送系统具有靶向性、缓释性和增加生物膜通透性以及降低药物毒副作用的优点。

pamam树状大分子结构具有高度的几何对称性、较多的官能团及分子内存在空腔等特点。

治疗药物可以通过静电作用或化学键合结合于pamam树状大分子表面，也可通过静电作用、疏水作用或氢键结合于大分子内部。

2. 参考文献

1. Xie Q, Zhou Y, Lan G, et al. Sensitization of cancer cells to radiation by selenadiazole derivatives by regulation of ROS-mediated DNA damage and ERK and AKT pathways. Biochem Biophys Res Commun. 2014; 449(1):88#8211;93. 2. ES, Player A. Nanotechnology, nanomedicine, and the development of a new, effective therapies for cancer. Nanomedicine. 2005; 1(2):101#8211;109. 3. Chaachouay H, Ohneseit P, Toulany M, Kehlbach R, Multhoff G, Rodemann HP. Autophagy contributes to resistance of tumor cells to ionizing radiation. Radiother Oncol. 2011;99(3):287#8211;292. 4. Kim R, Emi M, Tanabe K, et al. The role of apoptosis or nonapoptosis cell death in determining cellular response to anticancer treatment. EJSO. 2006;32(3):369#8211;377. 5. Zhang XD, Wu D, Shen X, et al. Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy. Biomaterials. 2012;33(27):6408#8211;6419. 6. Escamilla-Perea L, Nava R, Pawelec B, et al. SBA-15-supported gold nanoparticles decorated by CeO2: structural characteristics and CO oxidation activity. Appl Catal A. 2010;381(1#8211;2):42#8211;53. 7. Duncan, R., and Izzo, L. (2005). Dendrimer biocompatibility and toxicity. Adv. Drug. Deliv. Rev. 57, 2215#8211;2237. 8. Gelperina, S., Kisich, K., Iseman, M.D., and Heifets, L. (2005). The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis. Am. J. Resp. Crit. Care Med. 172, 1487#8211;1490. 9. Kitchens, K.M., Foraker, A.B., Kolhatkar, R.B., Swaan, P.W., and Ghandehari, H. (2007). Endocytosis and interaction of poly (amidoamine) dendrimers with Caco-2 cells. Pharm. Res. 24, 2138#8211;2145. 10. Kitchens, K.M., Kolhatkar, R.B., Swaan, P.W., and Ghandehari, H. (2008). Endocytosis inhibitors prevent poly(amidoamine) dendrimer internalization and permeability across Caco-2 cells. Mol. Pharm. 5, 364#8211;369. 11. Seib, F.P., Jones, A.T., and Duncan, R. (2007). Comparison of the endocytic properties of linear and branched PEIs, and cationic PAMAM dendrimers in B16f10 melanoma cells. J. Contr. Release 117, 291#8211;300. 12. Ryu JH, Koo H, Sun IC, et al. Tumor-targeting multi-functional nanoparticles for theragnosis: new paradigm for cancer therapy. Adv Drug Deliv Rev. 2012;64(13):1447#8211;1458. 13. Namiki Y, Fuchigami T, Tada N, et al. Nanomedicine for cancer: lipidbased nanostructures for drug delivery and monitoring. Acc Chem Res. 2011;44(10):1080#8211;1093. 14. Faraday M. The Bakerian Lecture: experimental relations of gold (and other metals) to light. Philos T R Soc A. 1857;147:145#8211;181. 15. Vigderman L, Zubarev ER. Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecules. Adv Drug Deliv Rev. 2013;65(5):663#8211;676. 16. Jain PK, Lee KS, El-Sayed IH, El-Sayed MA. Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J Phys Chem B. 2006;110(14):7238#8211;7248. 17. Orendorff CJ, Sau TK, Murphy CJ. Shape-dependent plasmon-resonant gold nanoparticles. Small. 2006;2(5):636#8211;639. 18. Agasti SS, Rana S, Park MH, Kim CK, You CC, Rotello VM. Nanoparticles for detection and diagnosis. Adv Drug Deliv Rev. 2010;62(3): 316#8211;328. 19. Liu H, Shen M, Zhao J, et al. Tunable synthesis and acetylation of dendrimer-entrapped or dendrimer-stabilized gold-silver alloy nanoparticles. Colloids Surf B Biointerfaces. 2012;94:58#8211;67. 20. Meir R, Motiei M, Popovtzer R. Gold nanoparticles for in vivo cell tracking. Nanomedicine (Lond). 2014;9(13):2059#8211;2069. 21. Lehenkari, P. P. et al. Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol. Pharmacol. 61, 1255#8211;1262 (2002). 22. Magda, D. Miller, R. A. Motexafin gadolinium: a novel redox active drug for cancer therapy. Semin. Cancer Biol. 16, 466#8211;476 (2006). 23. Ravikumar, B. et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nature Genet. 36, 585#8211;595 (2004).

3. 毕业设计（论文）进程安排

18. 2.26-18.3.4 文献查阅，了解课题 18. 3.5-18.3.11 英文文献翻译以及完成开题报告 18.3.12-18.4.4 按照实验计划进行试验 18.4.5-18.4.7 清明节休假 18.4.8-18.4.28 按照实验计划进行试验 18.4.29-18.4.30 进行中期检查 18.5.1-18.5.3 劳动节休假 18.5.4-18.5.31 进行实验并整理数据 18.6.1-18.6.14 撰写完成毕业论文 18.6.15-18.6.21 毕业论文答辩