1. 毕业设计（论文）的内容和要求

肽类树状大分子是新一代生物医用高分子材料，具有广阔的应用前景。

空间立体构象可影响肽类树状大分子的生物学活性。

本项目针对l型和d型肽类树状大分子，通过发散法，优化实验条件，制备化学结构精准的l型和d型纯手性肽类树状大分子。

2. 参考文献

[1] Darbre, T., Reymond, J. L. Peptide dendrimers as artificial enzymes, receptors, and drug-delivery agents. Accounts Chem.Res. 2006, 39, 925-934. [2] Lee, C. C., MacKay, J. A., Fr#233;chet, J. M., Szoka, F. C. Designing dendrimers for biological applications. Nat. Biotechnol. 2005, 23 1517-1526. [3] Sadler, K., Tam, J. P. Peptide dendrimers: applications and synthesis. Mol. Biotechnol. 2002, 90, 195-229. [4] Li, Y., Xu, X., Zhang, X., Li, Y., Zhang, Z., Gu, Z. Tumor-specific multiple stimuli-activated dendrimeric nanoassemblies with metabolic blockade surmount chemotherapy resistance. ACS Nano 2017, 11, 416#8722;429. [5] Zhang, X., Zhang, Z., Xu, X., Li, Y., Li, Y., Jian, Y., Gu, Z. Bioinspired therapeutic dendrimers as efficient peptide drugs based on supramolecular interactions for tumor inhibition. Angew. Chem. Int. Ed. 2015, 54, 4289-4294. [6] Hu, C., Xu, X., Zhang, X., Li, Y., Li, Y., Gu, Z. Bioinspired design of stereospecific D#8209;protein nanomimics for high efficiency autophagy induction. Chem. Mater. 2017, 2017, 29, 7658-7662.

3. 毕业设计（论文）进程安排

2-3月：查阅树状大分子相关文献，了解树状大分子合成方法研究现状，翻译外文文献1篇； 4月：合成纯手性肽类树状大分子，对其分子结构和手性特征进行表征与分析； 5月：撰写毕业论文、参加毕业论文答辩。