1. 毕业设计（论文）的内容和要求

肽类树状大分子是近年来发展起来的一类新型生物医用高分子材料，在药物及基因等递送方面具有广阔的应用前景。

本项目通过设计与合成聚赖氨酸树状大分子，建立系统的产物合成、纯化、理化性质表征和分析方法。

2. 参考文献

[1] Darbre, T., Reymond, J. L. Peptide dendrimers as artificial enzymes, receptors, and drug-delivery agents. Accounts Chem.Res. 2006, 39, 925-934. [2] Sadler, K., Tam, J. P. Peptide dendrimers: applications and synthesis. Mol. Biotechnol. 2002, 90, 195-229. [3] Grayson, S. M., Frechet, J. M. Convergent dendrons and dendrimers: from synthesis to applications. Chem. Rev. 2001, 101, 3819-3868. [4] Li, Y., Xu, X., Zhang, X., Li, Y., Zhang, Z., Gu, Z. Tumor-specific multiple stimuli-activated dendrimeric nanoassemblies with metabolic blockade surmount chemotherapy resistance. ACS Nano 2017, 11, 416#8722;429. [5] Xu, X., Jian, Y., Li, Y., Zhang, X., Tu, Z., Gu, Z. Bio-inspired supramolecular hybrid dendrimers self-Assembled from low-generation peptide dendrons for highly efficient gene delivery and biological tracking. ACS Nano 2014, 8, 9255-9264. [6] Zhang, Z., Zhang, X., Xu, X., Li, Y., Li, Y., Zhong, D., He Y., Gu, Z. Virus-inspired mimics based on dendritic lipopeptides for efficient tumor-specific infection and systemic drug delivery. Adv. Funct. Mater. 2015, 25, 5250-5260.

3. 毕业设计（论文）进程安排

2-3月：查阅肽类树状大分子相关文献，了解研究现状；翻译外文文献1篇； 4月：合成聚赖氨酸肽类树状大分子并对其结构进行表征与分析； 5月：撰写毕业论文、参加毕业论文答辩。