1. 毕业设计（论文）的内容和要求

低临界溶解温度lcst(lower critical solution temperature)类水凝胶可感知外界温度的细微变化并产生体积相变，这种特性引起了人们的极大关注，广泛应用于药物控制释放、分离膜、固定酶等方面。

代表性的lcst类水凝胶有聚n-异丙基丙烯酰胺(pnipaam)类，聚甲基乙烯基醚(mve)类，聚甲基丙烯酸羟乙酯(hema)类等，其中pnipaam水凝胶由于其lcst在32℃左右，与人体温度接近，若调节聚合物骨架中的亲水组分和疏水组分，lcst还可上下变化，因此其在lcst类水凝胶中尤受人们的青睐。

目前多数研究者认为nipaam分子热敏性与结构中的疏水性异丙基和亲水性酰胺基有关，它们分别位于凝胶网络中亲疏水区域，且存在亲疏水平衡。

2. 参考文献

【1】Carolina de las Heras Alarco#180;n, Sivanand Pennadam and Cameron Alexander*.Stimuli responsive polymers for biomedical applications. Stimuli responsive polymers for biomedical applications,2005,1632-1635. 【2】Chien-Chi Lin , Andrew T. Metters. Hydrogels in controlled release formulations: Network design and mathematical modeling. Advanced Drug Delivery Reviews,2006,2135-2442. 【3】Dong In Ha, Sang Bong Lee, Moo Sang Chong, and Young Moo Lee. Preparation of Thermo-Responsive and Injectable Hydrogels Based on Hyaluronic Acid and Poly(N-isopropylacrylamide) and Their Drug Release Behaviors. Macromolecular Research, 2006,4216-4219. 【4】Shinji Sugiura, Kimio Sumaru, Katsuhide Ohi, Kazuaki Hiroki,Toshiyuki Takagi, Toshiyuki Kanamori. Photoresponsive polymer gel microvalves controlled by local light irradiation. Elsevier ,2007,3668-3705. 【5】Frank Feyerabend, Janine Fischer, Jakob Holtz , Frank Witte , Regine Willumeit ,Heiko Dr#252;cker , Carla Vogt, Norbert Hort . Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines. Acta Biomaterialia(2010) 1834#8211;1842. 【6】Itsuro Tomatsu, Ke Peng, Alexander Kros. Photoresponsive hydrogels for biomedical applications. Advanced Drug Delivery Reviews 63 (2011) 1257#8211;1266. 【7】Shengtong Sun and Peiyi Wu. A one-step strategy for thermal- and pH-responsive graphene oxide interpenetrating polymer hydrogel networks. J. Mater. Chem., 2011, 21, 4095. 【8】George Pasparakis and Maria Vamvakaki. Multiresponsive polymers: nano-sized assemblies, stimuli-sensitive gels and smart surfaces. Polym. Chem., 2011, 1234#8211;1248. 【9】Zhichen Zhu, Erkan Senses, Pinar Akcora, and Svetlana A. Sukhishvili. Programmable Light-Controlled Shape Changes in Layered Polymer Nanocomposites. American Chemical Society,2012,3152-3162. 【10】Chun-Hua Zhu , Yang Lu , Jun Peng , Jia-Fu Chen , and Shu-Hong Yu. Photothermally Sensitive Poly( N -isopropylacrylamide)/Graphene Oxide Nanocomposite Hydrogels as Remote Light-Controlled Liquid Microvalves. Adv. Funct. Mater. 2012, 22, 4017#8211;4022. 【11】Evan M. White, Jeremy Yatvin, Joe B. Grubbs III, Jenna A. Bilbrey, Jason Locklin. Advances in Smart Materials: Stimuli-Responsive Hydrogel Thin Films. JOURNAL OF POLYMER SCIENCE, PART B: POLYMER PHYSICS 2013, 51, 1084#8211;1099. 【12】Eunsu Lee, Hyeonjin Lee, Seong Il Yoo, and Jinhwan Yoon. Photothermally Triggered Fast Responding Hydrogels Incorporating a Hydrophobic Moiety for Light-Controlled Microvalves. ACS Appl. Mater. Interfaces 2014, 6, 16949#8722;16955. 【13】Haneul Kim , Hyeonjin Lee , Keum-Yong Seong , Eunsu Lee , Seung Yun Yang , * and Jinhwan Yoon. Visible Light-Triggered On-Demand Drug Release from Hybrid Hydrogels and its Application in Transdermal Patches. Adv. Healthcare Mater. 2015, 4, 2071#8211;2077. 【14】Eunsu Lee, Dowan Kim, Haneul Kim Jinhwan Yoon. Photothermally driven fast responding photo-actuators fabricated with comb-type hydrogels and magnetite nanoparticles. Scientific Reports,2015. 【15】Mahdi Karimi, Parham Sahandi Zangabad, Alireza Ghasemi, Mohammad Amiri, Mohsen Bahrami, Hedieh Malekzad, Hadi Ghahramanzadeh Asl, Zahra Mahdieh,Mahnaz Bozorgomid, Amir Ghasemi, Mohammad Reza Rahmani Taji Boyuk,and Michael R. Hamblin. Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances. ACS Appl. Mater. Interfaces 2016, 8, 21107#8722;21133.

3. 毕业设计（论文）进程安排

1.4-3.1 文献查阅，文献翻译，开题报告 3.2-3.27 制备稀土配合物和水凝胶 3.30-4.20 性能表征与测试 4.20-5.4 中期总结，论文初稿 5.4-6.5 补充数据，完善论文 6.7-6.12 PPT制作，答辩