1. 毕业设计（论文）的内容和要求

生物医用镁合金具有良好的生物相容性，生物活性、可降解性，优异的综合力学等优点，被誉为第三代生物医用材料，有望替代不锈钢、钛合金等传统不可降解医用金属材料。

然而目前生物可降解镁合金存在腐蚀速率过快和腐蚀不均匀等问题，导致生物镁合金尚未满足临床使用要求，因而改善镁合金的乃是性能至关重要。

ae44镁合金是稀土系镁合金，前期研究发现耐蚀性较az系合金有了显著改善。

2. 参考文献

1. 刘正, 张奎, 曾小勤, 镁基轻质合金的理论基础及其应用[M], 北京: 机械工业出版社, 2002. 2. 宋光铃, 镁合金腐蚀与防护[M], 化工出版社, 2006. 3. 兰伟，孙建春，周安若，邱会东，张丁非, 镁合金表面处理技术的研究现状，2006，5(20): 428-430. 4. 卫英慧, 许并社, 镁合金腐蚀防护的理论与实践, 北京, 冶金工业出版社, 2008. 5. M.M. Stevens, Biomaterials for bone tissue engineering, Mater. Today 11 (2008) 18#8211;25. 6. Z. Chen, X. Mao, L. Tan, T. Friis, C. Wu, R. Crawford, et al., Osteo immuno modulatory properties of magnesium scaffolds coated with β-tricalcium phosphate, Biomaterials 35 (2014) 8553#8211;8565. 7. J. Wang, V. Giridharan, V. Shanov, Z. Xu, B. Collins, L. White, et al., Flow-induced corrosion behavior of absorbable magnesium-based stents, Acta Biomater. 10 (2014) 5213#8211;5223. 8. S. Kunjukunju, A. Roy, M. Ramanathan, B. Lee, J.E. Candiello, P.N. Kumta, A 9. layer-by-layer approach to natural polymer-derived bioactive coatings on magnesium alloys, Acta Biomater. 9 (2013) 8690#8211;8703. 10. M.-H. Kang, H.-D. Jung, S.-W. Kim, S.-M. Lee, H.-E. Kim, Y. Estrin, et al., Production and bio-corrosion resistance of porous magnesium with hydroxyapatite coating for biomedical applications, Mater. Lett. 108 (2013) 122#8211;124. 11. H. Hornberger, S. Virtanen, A.R. Boccaccini, Biomedical coatings on magnesium 12. alloys #8211; a review, Acta Biomater. 8 (2012) 2442#8211;2455. 13. H.M. Mousa, D.H. Lee, C.H. Park, C.S. Kim, A novel simple strategy for in situ deposition of apatite layer on AZ31B magnesium alloy for bone tissue regeneration, Appl. Surf. Sci. 351 (2015) 55#8211;65. 14. S. Shen, S. Cai, M. Zhang, G. Xu, Y. Li, R. Ling, et al., Microwave assisted deposition of hydroxyapatite coating on a magnesium alloy with enhanced corrosion resistance, Mater. Lett. 159 (2015) 146#8211;149. 15. J.-J. Guan, B. Tian, S. Tang, Q.-F. Ke, C.-Q. Zhang, Z.-A. Zhu, et al., Hydroxyapatite coatings with oriented nanoplate arrays: synthesis, formation mechanism and cytocompatibility, J. Mater. Chem. B 3 (2015) 1655#8211;1666. 16. S. Thelen, F. Barthelat, L.C. Brinson, Mechanics considerations for microporous titanium as an orthopedic implant material, J. Biomed. Mater. Res. A 69A (2004) 601#8211;610.

3. 毕业设计（论文）进程安排

2019-01-06～2019-01-18 查阅文献，撰写开题报告。

2019-02-26～2019-03-31 制定实验方案，开展ae44镁合金表面磷化处理研究，定期汇报实验进展。

2019-04-01～2019-04-29 优化工艺参数，制备厚度均匀，结构致密的磷化膜。