1. 毕业设计（论文）的内容和要求

课题的基本要求： （1）通过查阅文献，了解有关本课题的国内外研究现状； （2）学习和掌握有关试验技能； （3）以冠醚修饰的铱为体系，利用实验进行佐证其铱配合物探针的效果； （4）分析计算结果，撰写毕业论文。

预定完成任务及时间：2017年6月15日

2. 参考文献

[1] Isothermal Crystallization of Short Polymer Chains Induced by the Oriented Slab and the Stretched Bundle of Polymer: A Molecular Dynamics Simulation Jun-Sheng Yang, Chuan-Lu Yang,* Mei-Shan Wang, Bao-Dong Chen, and Xiao-Guang Ma School of Physics, Ludong University, Yantai 264025, People#8217;s Republic of China [2] Lo K K W, Chung C K, Lee T K, et al. New luminescent cyclometalated iridium(III) diimine complexes as biological labelingreagents[J]. Inorganic Chemistry, 2003, 42: 6886-6897. [3] Lo K K W, Chung C K, Zhu N. Synthesis, photophysical and electrochemical properties, and biological labeling studies of cyclometalated iridium(III) bis(pyridylbenzaldehyde) complexes: novel luminescent cross-linkers for bio-molecules[J]. Chem Eur J,2003, 9(2): 475-483. [4] Lo K K W, Chan J S W, Lui L H, et al. Novel luminescent cyclometalated iridium(III) diimine complexes that contain a biotin moiety[J]. Organometallics, 2004, 23: 3108-3116. [5] Lo K K W, Lau J S Y. Cyclometalated iridium(III) diimine bis(biotin) complexes as the first luminescent biotin-based cross-linkers for avidin[J]. Inorganic Chemistry, 2007, 46: 700-709. [6] Lo K K W, Zhang K Y, Chung C K, et al. Synthesis, photophysical and electrochemical properties, and protein-binding studies of luminescent cyclometalated iridium(III) bipyridine estradiol conjugates[J]. Chem Eur J, 2007, 13: 7110-7120. [7] Kwon T H, Kwon J, Hong J I, et al. Signal amplification via intramolecular energy transfer using tripodal neutral iridium(III)Vcomplexes upon binding to avidin[J]. J Am Chem Soc, 2008, 130: 3726-3727. [8] Lo K K W, Zhang K Y, Leung S K, et al. Exploitation of the dual-emissive properties of cyclometalated iridium(III)- polypyridinecomplexes in the development of luminescent biological probes[J]. Angew Chem Int Ed, 2008, 47: 2213-2216. [9] Shao F W, Barton J K. Long-range electron and hole transport through DNA with tethered cyclometalated iridium(III) complexes[J].J Am Chem Soc, 2007, 129: 14733-14738. [10] Ma D L, Wong W L, Chung W H, et al. A highly selective luminescent switch-on probe for histidine/histidine-rich proteins andits application in protein staining[J]. Angew Chem Int Ed, 2008, 47: 3735-3739 [11] Lai C W, Wang Y H, Lai C H, et al. Iridium-complex-functionalized Fe3O4/SiO2 core/shell nanoparticles: a facile three-in-one [12] Chen H L, Zhao Q, Wu Y B, et al. Selective phosphorescence chemosensor for homocysteine based on an Iridium(III) complex[J].Inorganic Chemistry, 2007, 46: 11075-11081. [13] Yu M X, Zhao Q, Shi L X, et al. Cationic iridium(III) complexes for phosphorescence staining in the cytoplasm of living cells[J].Chem Commun, 2008, 2115-2117. [14] Xue G H, Yong W, Hong T C, et al. A cationic iridium(III) complex with aggregationinduced emission (AIE) properties for highlyselective detection of explosives[J]. Chem. Commun., 2014, 50, 6031#8212;6034.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 备 注 2017-03-01~2017-04-11 系统地检索和阅读相关中外文文献，了解该课题的国内外研究现状。

学习和掌握有关实验技能。

完成开题报告。