1. 毕业设计（论文）的内容和要求

内容基本要求：1. 概念准确，层次清楚，内容正确，格式规范。

2. 字体工整，字迹清楚，行文流畅，无错别字。

3. 有关于课题的条件、技术、经济等方面的可行性分析。

2. 参考文献

[1] H.M. Lee, M. Ge, B.R. Sahu, P. Tarakeshwar, K.S. Kim, Geometrical and electronic structures of gold, silver, and gold-silver binary clusters: origins of ductilityof gold and gold-silver alloy formation, J. Phys. Chem. B 107 (2003) 9994#8211;10005. [2] J. Zheng, P.R. Nicovich, R.M. Dickson, Highly #64258;uorescent noble-metal quantum dots, Annu. Rev. Phys. Chem. 58 (2007) 409#8211;431. [3] Valko, M.; Leibfritz, D.; Moncol, J.; Cronin, M. T.; Mazur, M.; Telser, J. Free Radicals and Antioxidants in Normal Physiological Functions and Human Disease. Int. J. Biochem. Cell Biol. 2007, 39, 44#8211;84. [3] N. Schaeffer, B. Tan, C. Dickinson, M.J. Rosseinsky, A. Laromaine, D.W. McComb, et al., Fluorescent or not? Size-dependent #64258;uorescence switching for polymer- stabilized gold clusters in the 1.1#8211;1.7 nm size range, Chem. Commun. 34 (2008)3986#8211;3988. [4] L.Y. Chen, C.W. Wang, Z. Yuan, H.T. Chang, Fluorescent gold nanoclusters: recent advances in sensing and imaging, Anal. Chem. 87 (2014) 216#8211;229. [6] He, W.; Wu, X.; Liu, J.; Hu, X.; Zhang, K.; Hou, S.; Zhou, W.; Xie, S. Design of AgM Bimetallic Alloy Nanostructures (M=Au, Pd, Pt) with Tunable Morphology and Peroxidase-Like Activity. Chem. Mater. 2010, 22, 2988#8211;2994. [5] Lee J S, Lytton-Jean A K R, Hurst S J and Mirkin C A 2007 Silver nanoparticle oligonucleotide conjugates based on DNA with triple cyclic disul#64257;de moieties Nano L ett. 7 2112#8211;5. [6] Murphy C J et al 2008 Chemical sensing and imaging with metallic nanorods Chem. Commun. 5544#8211;7. [7] X.Q. Liao, R.Y. Li, Z.J. Li, X.L. Sun, Z.P. Wang, J.K. Liu, Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their appli cation for the #64258;uorescence detection of Hg2 in water samples, New J. Chem. 39 (2015) 5240#8211;5248. [8] C.X.Wang,H.Cheng,Y.J.Huang,Z.Z.Xu,H.H.Lin,C.Zhang,Facilesonochemical synthesis of pH-responsive copper nanoclusters for selective and sensitive detection of Pb2 in living cells, Analyst 140 (2015) 5634#8211;5639. [9] Y. Ling, N. Zhang, F. Qu, T. Wen, Z.F. Gao, N.B. Li, et al., Fluorescent detection of hydrogen peroxide and glucose with polyethyleneimine-templated Cu nanoclusters, Spectrochim. Acta A 118 (2014) 315#8211;320. [10] X. Jia, X. Yang, J. Li, D. Li, E.K. Wang, Stable Cu nanoclusters: from an aggregation-induced emission mechanism to biosensing and catalytic applications, Chem. Commun. 50 (2014) 237#8211;239. [11] H. Chen, L. Lin, H. Li, J. Li, J.M. Lin, Aggregation-induced structure transition of protein-stabilized zinc/copper nanoclusters for ampli#64257;ed chemiluminescence, ACS Nano 9 (2015) 2173#8211;2183. [12] X. Kang, Z. Mai, X. Zou, P. Cai, J. Mo, A sensitive nonenzymatic glucose sensor in alkaline media with a copper nanocluster/multiwall carbon nanotube modi#64257;ed glassy carbon electrode, Anal. Biochem. 363 (2007) 143#8211;150. [13] L. Hu, Y. Yuan, L. Zhang, J. Zhao, S. Majeed, G. Xu, Copper nanoclusters as peroxida semimetics and their applications to H2O2 and glucose detection, Anal. Chim. Acta 762 (2013) 83#8211;86.

3. 毕业设计（论文）进程安排

3月01日至3月10日，了解相关文献以及完成翻译工作。

3月10日至3月31日，制备纳米cu团簇。

4月1日至5月20日，研究在合适的条件下利用cu团簇为探针实现h2o2和重金属离子的检测。