1. 毕业设计（论文）的内容和要求

内容： 文献检索，了解课题背景；翻译英文论文一篇；开展生物检测试剂的开发研究，进行实验；完成毕业论文。

要求： （1） 培养查阅文献能力，能够借助工具书翻译英文文献。

（2） 参考文献指导，结合自己的课题，独立设计自己的实验步骤，初步培养一定的科研能力。

2. 参考文献

[1] Zhou P, Shi R. F,Yao J. F, Sheng C. F, Li H. Supramolecular self-assembly of nucleotide-metal coordination complexes: From simple molecules to nanomaterials[J]. Coord. Chem. Rev. 2015, 292: 107-143. [2] Aoki K. General conclusions from solid state studies of nucleotide-metal ion complexes[J]. Met. Ions Biol. Syst. 1996, 32: 91-134. [3] Clark G. R, Orbell J. D. Polymeric Metal-Nucleotide Complexes-Crystal-Struc-tures of [(C9H12H3O8P)Co(H2O)旽2O]n and [(C9H12N3O8P)Co(H2O)]n Formed betwe-en Cadmium(II) or Cobalt(II) Ions and Cytidine 5'-Monophosphate[J]. Acta Cryst-allogr. Sect. B: Struct.Sci. 1978, 34: 1815-1822. [4] Goodgame D. M. L, Jeeves I, Reynolds C. D, Skapski A. C. Heavy Metal-Pyrimidine Nucleotide Interaction-X-Ray Structure of a Cadmium Derivative of Cytidine 5'-Monophosphate[J]. Biochem.J. 1975, 151: 467-468. [5] Shiba J. K, Bau R. Crystal and Molecular-Structure of Monoclinic Form of [Cd(5'-CMP)(H2O)]n[J]. Inorg. Chem. 1978, 17: 3484-3488. [6] Cartwright B. A, Goodgame D. M. L, Jeeves I, Skapski A. C. X-Ray Struct-ure of a Compound of Cobalt with Uridine 5'-Monophosphate Evidence for Metal-Phosphate Bonding Only[J]. Biochim. Biophys. Acta. 1977, 477: 195-198. [7] Aoki K, Saenger W. Crystal-Structures of Cadmium(II) Complexes with Uri-dine 5'-Monophosphate (5'-UMP), [Cd(5'-UMP)(H2O)2]?H2O, and with 2'-Deoxyur-idine 5'-Monophosphate (5?dUMP), [Cd2(5'-dUMP)2(H2O)6]-Phosphate-Only Metal-Bonding[J]. Dalton Trans. 1984, 1401-1409. [8] Aoki K. X-Ray crystal structures of the ternary complexes [Cd(5'-[prime or minute]-UMP)(dpa)(H2O)2](5'-[prime or minute]-UMP[double bond, length as m-da-sh]uridine 5'-[prime or minute]-phosphate, dpa[double bond, length as m-dash] 2, 2'-[prime or minute]-dipyridylamine): metalion bridged stacking between nucleotidebases and aromatic amine rins, and [Cu(5'-[prime or minute]-CMP)(dpa(H2O)]2(5'-[prime or minute]-CMP [double bond, length as m-dash]cytidine 5'-[prime or min-ute]-phosphae): phosphate only metal bondin[J]. Chem. Commun. 1979, 589-591. [9] Meester P. D, Goodgame D. M, Price K. A, Skapski A. C. X-Ray Crystal Structure of [Cu(Adenineh)2Br2]Br2-Copper Complex Involving Non-Bridgig Adeni-ne[J]. Biochem. Biophys. Res. Commun. 1971, 44: 510-512. [10] Terada H, Iwakaji E, Hiramatsu K, Aoki K. Characterization of Component of Heat-Treated Serum-Albumin with Bromcresol Green[J]. Biochim. Biophys. Ac-ta. 1976, 453: 26-36. [11] Aoki K. Interactions of metal ions with nucleotides. Metal bonding to N(7) in the ternary copper(II)-inosine 5[prime or minute]-phosphate complex [Cu(5'-[p-rime or minute]-IMP)(2,2'-[prime or minute]-bipyridyl)(H2O)2][middle dot]NO3[mid-dle dot]H2O: X-ray crystal structure analysis, and metal bonding to both N(7) andphosphate in the binary complex [Cu(5'-[prime or minute]-IMP)][middle dot]H2O: X-ray characterization[J]. Chem. Commun. 1977, 600-602. [12] Fiol J. J, Terr髇 A, Calafat A. M, Moreno V, Aguil?M, Solans. Crystal st-ructures and spectroscopic studies of ternary compounds of Ni(II) with ethylenedi-amine and 5'-GMP and 5'-IMP[J]. J. Inorg. Biochem. 1989, 35: 191-214. [13] Holliday B. J, Mirkin C. Strategies for the Construction of Supramolecular Compounds through Coordination Chemistry[J]. Angew Chem. Int. Ed. 2001, 40: 2022-2043. [14] Leininger S, Olenyuk B, Stang P. Self-assembly of discretecyclic nanostruct-ures mediated by transition metals[J]. Chem. Rev. 2000, 100: 853-907. [15] Steel P. J. Ligand Design in Multimetallic Architectures:#8201;Six Lessons Learned[J]. Acc. Chem. Res. 2005, 38: 243-250. [16] Ma L. F, Li X. Q, Meng Q. L, Wang L. Y, Du M, Hou H. W. SignificantPositional Isomeric Effect on Structural Assemblies of Zn(II) and Cd(II) Coordin-ation Polymers Based on Bromoisophthalic Acids and Various Dipyridyl-Type Co-ligands[J]. Crystal GrowthDesign. 2011, 11: 175-184. [17] Chakrabarty R, Mukherjee P. S, Stang P. Supramolecular Coor-dination: Self-Assembly of Finite Two-and Three-Dimensional Ensembles[J]. Chem. Rev. 2011, 111: 6810-6918. [18] Zhou P, Wang C, Qiu Q. M, Yao J. F, Sheng C. F, Li H. Controllable sy-nthesis of nucleotide complex based on pH control: a small-molecule fluorescent probe as an auxiliary ligand to indicatethe preorganization of the nucleotide com-plex in solution[J]. Dalton Trans. 2015, 44: 17810-17818. [19] Wood R. M, Palenik G. J. Bond Valence Sums in Coordination Chemistry Sodium#8722;Oxygen Complexes[J]. Inorg. Chem. 1999, 38: 3926-3930. [20] Gdaniec M, Polonski T. Generation of chirality in guest aromatic ketones in-cluded in the crystals of steroidalbile acids[J]. J. Am. Chem. Soc. 1998, 120: 7353-7354. [21] Paluch M, Gawryszewska P, Lis T, Lisowski J. Chiral macrocyclic lanthani-de complexes derived from (R)-2, 2'-diamino-1, 1'-binaphthyl: X-ray crystal struct-ure and luminescence studies[J]. Polyhedron. 2010, 29: 3387-3393.

3. 毕业设计（论文）进程安排

2018.3.1-2018.3.10 要完成这方面的文献资料查阅，写好开题报告，并完成一篇英文文献的翻译。

2018.3.11-2018.5.22根据文献，设计合成路线，合成腺苷类配合物，并做相关表征。

2018.5.23-2018.6.13 完成毕业论文的撰写及答辩。