1. 毕业设计（论文）的内容和要求

毕业论文包含四部分内容：1.文献综述：综述目前关于DNA染色细胞核的研究现状；2.合成一类噻唑橙类探针分子，学会分析图谱及结构鉴定；3.将合成纯化的染料分子用于细胞核成像研究；4.总结；5.参考文献

2. 参考文献

[1] L. J. Kricka, P. Fortina, Clin. Chem. 2009, 55, 670 #8211; 683. [2] G.-L. Law, C. Man, D. Parker, J. W. Walton, Chem. Commun. 2010, 46, 2391 #8211; 2393. [3] A. Erve, Y. Saoudi, S. Thirot, C. Guetta-Landras, J.-C. Florent, C.-H. Nguyen, D. S. Grierson, A. V. Popov, Nucleic Acids Res. 2006, 34, e43. [4] S. Feng, Y. K. Kim, S. Yang, Y. T. Chang, Chem. Commun. 2010, 46, 436 #8211; 438. [5] M. R. Gill, J. Garcia-Lara, S. J. Foster, C. Smythe, G. Battaglia, J. A. Thomas, Nat. Chem. 2009, 1, 662 #8211; 667. [6] R. P. Haugland, The Handbook: A Guide to Fluorescent Probes and Labeling Technologies, 2005, chap. 8.1. For more detailed information see the website: www.invitrogen.com/site/us/en/ home/References/Molecular-Probes-The-Handbook.html. [7] a) S. K. Davis, C. J. Bardeen, Photochem. Photobiol. 2003, 77, 675 #8211; 679; b) G. P. Pfeifer, Y.-H. You, A. Besaratinia, Mutat. Res. 2005, 571, 19 #8211; 31. [8] a) P. J. Smith, N. Blunt, M. Wiltshire, T. Hoy, P. Teesdale-Spittle, M. R. Craven, J. V. Watson, W. B. Amos, R. J. Errington, L. H. Patterson, Cytometry 2000, 40, 280 #8211; 291; b) K. Wojcik, J. W. Dobrucki, Cytometry Part A 2008, 73, 555 #8211; 562. [9] a) A. Frstenberg, M. D. Julliard, T. G. Deligeorgiev, N. I. Gadjev, A. A. Vasilev, E. Vauthey, J. Am. Chem. Soc. 2006, 128, 7661 #8211; 7669; b) G. L. Silva, V. Ediz, D. Yaron, B. A. Armitage, J. Am. Chem. Soc. 2007, 129, 5710 #8211; 5718. [10] S. O. Kelley, J. K. Barton, Science 1999, 283, 375 #8211; 381. [11] K. C. Hannah, B. A. Armitage, Acc. Chem. Res. 2004, 37, 845 #8211; 853

3. 毕业设计（论文）进程安排

2018.02.26-2018.03.26 文献综述 2018.02.26-2018.04.26 探针分子合成 2018.04.26-2018.05.15 细胞核成像实验 2018.05.15-2018.05.30 撰写毕业论文