论文总字数：21638字

摘 要

聚合物微球在生物医药行业，材料化学行业和石油化工行业应用非常普遍，其中聚苯乙烯和聚甲基丙烯酸甲酯制备的聚合物微球以其优异的材料性能而具有更普遍的应用。然而制备这种微球的方法多数是间歇式操作且不能连续化制备，一般有悬浮聚合法、分散聚合法和乳液聚合法等，与这些方法相比，本实验采用微结构混合器基于纳米沉淀法制备聚苯乙烯（PS）与聚甲基丙烯酸甲酯(PMMA)复合微球，制备方法可以实现连续化操作而且制备的聚合物微球球形度好且粒径分布均匀，具有较高的单分散性。首先通过考察溶剂与反溶剂的混合形式选用了同轴微结构混合器，随后采用不同的溶剂与反溶剂体系制备同一聚合物微球在稳定性上体现出了差异性，最终选用了四氢呋喃与水作为制备PS-PMMA聚合物微球的溶剂与反溶剂体系。通过考察溶质浓度、流量比和总流量对制备PS-PMMA聚合物微球粒径及其粒径分布的影响因素可以看出： PS-PMMA聚合物微球的粒径随溶质的含量（溶液浓度）增大而增大；PS-PMMA 聚合物微球的粒径随流量比（PS-PMMA溶液浓度与去离子水两相流量比）的增大而减小；PS-PMMA聚合物微球的粒径随总流量的增大而减小；制备的PS-PMMA复合微球粒径介于50-200nm之间，CV值小于0.3。随后考察了瞬时纳米沉淀法制备聚合物微球的适用性，分别制备了PS、PMMA、PLA（聚乳酸）、PS-PLA、PS-PMMA、PLA-PMMA和PS-PLA-PMMA聚合物微球。

关键词:聚合物微球 聚苯乙烯 聚甲基丙烯酸甲酯 微结构混合器 瞬时纳米沉淀

Study on Continuous Preparation of Organic Composite

abstract

Polymer microspheres are very popular in the biomedical, materials and petrochemical industries, and polymer microspheres prepared from polystyrene and polymethyl methacrylate have more general applications due to their superior material properties. However, most of the methods for preparing such microspheres are batch operation and cannot be continuously prepared. Generally, suspension polymerization, dispersion polymerization, and emulsion polymerization are used. Compared with these methods, the experiment uses nanostructure mixer technology to utilize nanometers. Polystyrene and polymethyl methacrylate (PS-PMMA) composite microspheres were prepared by precipitation method. The preparation method was continuous and the prepared polymer microspheres had good sphericity and uniform particle size distribution, and had high monodispersity. Firstly, the coaxial micro-structure mixer was selected by investigating the mixture of solvent and anti-solvent. The difference between the different polymer microspheres prepared by different solvents and anti-solvent system showed the difference in stability. Finally, tetrahydrofuran and water were selected as the solvent and anti-solvent system for preparing PS-PMMA polymer microspheres. By examining the effects of solute concentration, flow rate ratio and total flow rate on the particle size and particle size distribution of PS-PMMA polymer microspheres, it can be seen that the particle size of PS-PMMA polymer microspheres varies with the solute content (solution concentration). Increase and increase; the particle size of PS-PMMA polymer microspheres increases with the flow rate ratio (the ratio of the two-phase flow rate of deionized water to PS-PMMA solution concentration); the particles of PS-PMMA polymer microspheres The diameter decreases as the total flow rate increases; the prepared PS-PMMA composite microspheres have a particle

size between 50 and 200 nm and a CV value of less than 0.3. Subsequently, the applicability of the preparation of polymer microspheres by transient nanoprecipitation was investigated. PS, PMMA, PLA, PS-PLA, PS-PMMA, PLA-PMMA and PS-PLA-PMMA polymer microspheres were prepared.

Key Words: polymer microspheres; polystyrene; polymethylmethacrylate; microstructure mixer; Flash nanoprecipitation

目 录

摘要…………………………………………………………………………………I

ABSTRACT………………………………………………………………………ⅰ

第一章 绪 论 1

1.1引言 1

1.1.1研究目标 1

1.1.2 研究方法 1

1.2 聚合物微球 2

1.2.1 聚合物微球简介 2

1.2.2 聚合物微球制备方法 2

1.2.3 聚合物微球的应用 5

1.3 微流体技术在制备聚合物微球方面的研究 6

第二章 实验部分 9

2.1实验试剂及仪器 9

2.2实验装置图 10

2.3 PS-PMMA复合微球的制备 10

2.4 粒径大小及分布表征 10

第三章 结果与讨论 13

3.1 引言 13

3.2 微结构反应器混合形式选择 13

3.3 溶剂与反溶剂的选择 15

3.4 溶质含量的影响 17

3.5 流量比的影响 17

3.6 总流量的影响 18

3.7 聚合物微球制备方法的适用性 19

第四章 结论 23

参考文献 25

致 谢 29

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