1. 毕业设计（论文）的内容和要求

1. 熟悉 web of sciense、scifinder等检索工具的使用，学习文献检索技巧；锻炼英文文献阅读理解，完成一篇英文文献翻译。

2. 学习合成化学实验的过程，独立开展实验，结合实践加深对有机化学的理解。

3. 初步了解核磁，红外，hplc，gc等常用分析仪器的原理及相关图谱解析，强化对实验结果的总结和分析能力，独立撰写学位论文。

2. 参考文献

[1] Jeon O Y, Carreira E M. Differential Interaction of an AmB Analogue and Ergosterol in Enantiomeric Membranes[J]. Org. Lett., 2010, 12(8): 1772-1775; [2] Chen H X, Kang J, Chang R, et al. Synthesis of α,α-Difluorinated Phosphonate pSer/pThr Mimetics via Rhodium-Catalyzed Asymmetric Hydrogenation of β-Difluorophosphonomethyl α-(Acylamino)acrylates[J]. Org. Lett., 2018, 20(11): 3278#8211;3281; [3] Cui J, Kawatake S, Umegawa Y, et al. Stereoselective synthesis of the head group of archaeal phospholipid PGP-Me to investigate bacteriorhodopsin#8211;lipid interactions[J]. Org. Biomol. Chem., 2015, 13, 10279-10284; [4] Hansj#246;rg Eibl. Phospholipid synthesis: Oxazaphospholanes and dioxaphospholanes as intermediates[J]. Proc. Nati. Acad. Sci. USA, 1978, 75(9): 4074-4077； [5] Ter Horst B, Seshadri C, Sweet L, et al. Asymmetric synthesis and structure elucidation of a glycerophospholipid from Mycobacterium tuberculosis[J]. J. Lipid Res., 2010, 51(5): 1017-1022; [6] Burugupalli S, Richardson M, Williams S J. Total synthesis and mass spectrometric analysis of a Mycobacterium tuberculosis phosphatidylglycerol featuring a two-step synthesis of (R)-tuberculostearic acid[J]. Org. Biomol. Chem., 2017, 15: 7422-7429; [7] Patil P S, Cheng T J R, Zulueta M M L, et al. Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity[J]. Nat. Commun., 2015, 6: 7239; [8] Mallik S , Prasad R , Bhattacharya A , et al. Synthesis of Phosphatidylserine and Its Stereoisomers: Their Role in Activation of Blood Coagulation[J]. ACS Med. Chem. Lett., 2018, 9 (5): 434-439; [9] Saikia B, Devi T J, Barua N C. First total synthesis of Debilisone C[J]. Org. Biomol. Chem., 2013, 11: 905-913; [10] Mercer J A M, Cohen C M, Shuken S R, et al. Chemical Synthesis and Self-Assembly of a Ladderane Phospholipid[J]. J. Am. Chem. Soc., 2016, 138: 15845-15848.

3. 毕业设计（论文）进程安排

2019/2/25 - 2019/3/15：检索文献，确定合成路线；翻译一篇文献；学习实验技能。

2019/3/15 - 2019/4/15：优化反应条件，完成克级关键中间体二脂肪酸甘油的合成。

2019/4/15 - 2019/5/15： 筛选不同的磷源试剂，确定最优条件，完成dspe的人工合成。