1. 毕业设计（论文）的内容和要求

查阅相关文献与专业书籍了解目前水滑石制备方面研究的现状，了解该材料相关背景，了解其在羟醛缩合反应催化中的应用，已有成果以及存在的问题，对论文的研究方向有较深入的认识。

本课题研究使用无表面活性剂反相微乳液法（sfme）制备纳米水滑石材料及将其应用于aldol缩合反应中，并对水滑石材料的酸碱性对探针反应的影响进行探究。

本课题的研究手段： 1.查阅文献，了解课题相关背景，实验方法等； 2. 利用sfme法完成不同mg:al的纳米水滑石的制备； 3.考察催化剂结构；通过红外，xrd，sem 等手段表征与测定催化剂的机构和形貌。

2. 参考文献

[1]. Motokura, K.;Tomita, M.;Tada, M.;Iwasawa, Y.; Acid-base bifunctional catalysis of silica-alumina-supported organic amines for carbon-carbon bond-forming reactions[J]. Chemistry-a European Journal, 2008, 14, 4017-4027. [2]. Huang, Y.L.;Trewyn, B.G.;Chen, H.T.;Lin, V.S.Y.; One-pot reaction cascades catalyzed by base- and acid-functionalized mesoporous silica nanoparticles[J]. New Journal of Chemistry, 2008, 32, 1311-1313. [3]. Motokura, K.;Tada, M.;Iwasawa, Y.; Acid-base bifunctional catalytic surfaces for nucleophilic addition reactions[J]. Chemistry-an Asian Journal, 2008, 3, 1230-1236. [4]. Shylesh, S.;Thiel, W.R.; Bifunctional Acid-Base Cooperativity in Heterogeneous Catalytic Reactions: Advances in Silica Supported Organic Functional Groups[J]. Chemcatchem, 2011, 3, 278-287. [5]. Bass, J.D.;Solovyov, A.;Pascall, A.J.;Katz, A.; Acid-base bifunctional and dielectric outer-sphere effects in heterogeneous catalysis: A comparative investigation of model primary amine catalysts[J]. Journal of the American Chemical Society, 2006, 128, 3737-3747. [6]. Bass, J.D.;Katz, A.; Bifunctional surface imprinting of silica: Thermolytic synthesis and characterization of discrete thiol-amine functional group pairs[J]. Chemistry of Materials, 2006, 18, 1611-1620. [7]. Coutinho, D.;Madhugiri, S.;Balkus, K.J.; Synthesis and characterization of organosilane functionalized DAM-1 mesoporous silica[J]. Journal of Porous Materials, 2004, 11, 239-254. [8]. Huh, S.;Chen, H.T.;Wiench, J.W.;Pruski, M.;Lin, V.S.Y.; Controlling the selectivity of competitive nitroaldol condensation by using a bifunctionalized mesoporous silica nanosphere-based catalytic system[J]. Journal of the American Chemical Society, 2004, 126, 1010-1011. [9]. Bouhrara, M.;Ranga, C.;Fihri, A.;Shaikh, R.R.;Sarawade, P.;Emwas, A.H.;Hedhili, M.N.;Polshettiwar, V.; Nitridated Fibrous Silica (KCC-1) as a Sustainable Solid Base Nanocatalyst[J]. Acs Sustainable Chemistry Engineering, 2013, 1, 1192-1199. [10]. Motokura, K.;Tada, M.;Iwasawa, Y.; Layered Materials with Coexisting Acidic and Basic Sites for Catalytic One-Pot Reaction Sequences[J]. Journal of the American Chemical Society, 2009, 131, 7944- . [11]. Huh, S.;Chen, H.T.;Wiench, J.W.;Pruski, M.;Lin, V.S.Y.; Cooperative catalysis by general acid and base bifunctionalized mesoporous silica nanospheres[J]. Angewandte Chemie-International Edition, 2005, 44, 1826-1830. [12]. Shylesh, S.;Wagener, A.;Seifert, A.;Ernst, S.;Thiel, W.R.; Mesoporous Organosilicas with Acidic Frameworks and Basic Sites in the Pores: An Approach to Cooperative Catalytic Reactions[J]. Angewandte Chemie-International Edition, 2010, 49, 184-187. [13]. Zeidan, R.K.;Hwang, S.J.;Davis, M.E.; Multifunctional heterogeneous catalysts: SBA-15-containing primary amines and sulfonic acids[J]. Angewandte Chemie-International Edition, 2006, 45, 6332-6335. [14]. Sharma, K.K.;Buckley, R.P.;Asefa, T.; Optimizing Acid-Base Bifunctional Mesoporous Catalysts for the Henry Reaction: Effects of the Surface Density and Site Isolation of Functional Groups[J]. Langmuir, 2008, 24, 14306-14320. [15]. Motokura, K.;Tada, M.;Iwasawa, Y.; Heterogeneous organic base-catalyzed reactions enhanced by acid supports[J]. Journal of the American Chemical Society, 2007, 129, 9540- . [16]. Polshettiwar, V.;Varma, R.S.; Green chemistry by nano-catalysis[J]. Green Chemistry, 2010, 12, 743-754. [17]. Corma, A.;Diaz, U.;Garcia, T.;Sastre, G.;Velty, A.; Multifunctional Hybrid Organic-Inorganic Catalytic Materials with a Hierarchical System of Well-Defined Micro- and Mesopores[J]. Journal of the American Chemical Society, 2010, 132, 15011-15021. [18]. Xie, Y.W.;Sharma, K.K.;Anan, A.;Wang, G.;Biradar, A.V.;Asefa, T.; Efficient solid-base catalysts for aldol reaction by optimizing the density and type of organoamine groups on nanoporous silica[J]. Journal of Catalysis, 2009, 265, 131-140. [19]. Goyal, R.;Sarkar, B.;Lucus, N.;Bordoloi, A.; Acid-Base Cooperative Catalysis over Mesoporous Nitrogen-Rich Carbon[J]. Chemcatchem, 2014, 6, 3091-3095. [20]. Voit, B.; Sequential one-pot reactions using the concept of "Site isolation"[J]. Angewandte Chemie-International Edition, 2006, 45, 4238-4240. [21]. Groger, H.; The development of new monometallic bifunctional catalysts with Lewis acid and Lewis base properties, and their application in asymmetric cyanation reactions[J]. Chemistry-a European Journal, 2001, 7, 5247-5251. [22]. Gelman, F.;Blum, J.;Avnir, D.; One-pot reactions with opposing reagents: Sol-gel entrapped catalyst and base[J]. Journal of the American Chemical Society, 2000, 122, 11999-12000. [23]. Bass, J.D.;Anderson, S.L.;Katz, A.; The effect of outer-sphere acidity on chemical reactivity in a synthetic heterogeneous base catalyst[J]. Angewandte Chemie-International Edition, 2003, 42, 5219-5222.

3. 毕业设计（论文）进程安排

3月中旬完成开题报告；3月中旬-4月底完成实验内容及开始论文的撰写；5月上交论文初稿