1. 毕业设计（论文）的内容和要求

本课题涉及合成具有过氧化氢和谷胱甘肽双重响应的吡咯并吡咯二酮（DPP）衍生物，通过二茂铁官能团催化过氧化氢分解形成高活性的羟基自由基，提升细胞氧化应激，并结构二硫键的谷胱甘肽响应性质，破坏癌细胞内部氧化还原性质，通过光热作用和氧化应激共同作用，破坏癌细胞的膜结构、DNA和蛋白质，促使细胞失能，达到杀死癌细胞并消除肿瘤的目的。

2. 参考文献

1、Tang Z, Liu Y, He M, et al. Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions[J]. Angewandte Chemie International Edition, 2019, 58(4): 946-956. 2、Shen Z, Liu T, Li Y, et al. Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors[J]. ACS nano, 2018, 12(11): 11355-11365. 3、Feng L, Xie R, Wang C, et al. Magnetic Targeting, Tumor Microenvironment-Responsive Intelligent Nanocatalysts for Enhanced Tumor Ablation[J]. ACS nano, 2018, 12(11): 11000-11012. 4、Liu Y, Zhen W, Jin L, et al. All-in-one theranostic nanoagent with enhanced reactive oxygen species generation and modulating tumor microenvironment ability for effective tumor eradication[J]. ACS nano, 2018, 12(5): 4886-4893. 5、Cheng H, Zhu J Y, Li S Y, et al. An O2 self‐sufficient biomimetic nanoplatform for highly specific and efficient photodynamic therapy[J]. Advanced Functional Materials, 2016, 26(43): 7847-7860. 6、Zhang K, Meng X, Cao Y, et al. Metal#8211;Organic Framework Nanoshuttle for Synergistic Photodynamic and Low‐Temperature Photothermal Therapy[J]. Advanced Functional Materials, 2018, 28(42): 1804634。

7、Zhang C, Bu W, Ni D, et al. Synthesis of iron nanometallic glasses and their application in cancer therapy by a localized Fenton reaction[J]. Angewandte Chemie International Edition, 2016, 55(6): 2101-2106. 8、Lin L S, Song J, Song L, et al. Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO2‐Based Nanoagent to Enhance Chemodynamic Therapy[J]. Angewandte Chemie, 2018, 130(18): 4996-5000. 9、Liu Y, Zhen W, Wang Y, et al. One-Dimensional Fe2 P Acts as a Fenton Agent in Response to NIR II Light and Ultrasound for Deep Tumor Synergetic Theranostics[J]. Angewandte Chemie (International ed. in English), 2019, 58(8): 2407. 10、Wang Y, Yin W, Ke W, et al. Multifunctional polymeric micelles with amplified fenton reaction for tumor ablation[J]. Biomacromolecules, 2018, 19(6): 1990-1998. 11、Ma B, Wang S, Liu F, et al. Self-Assembled Copper#8211;Amino Acid Nanoparticles for in Situ Glutathione ”AND” H2O2 Sequentially Triggered Chemodynamic Therapy[J]. Journal of the American Chemical Society, 2018, 141(2): 849-857. 12、Yu Z, Zhou P, Pan W, et al. A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis[J]. Nature communications, 2018, 9(1): 5044. 13、Tang W, Fan W, Wang Z, et al. Acidity/Reducibility Dual-Responsive Hollow Mesoporous Organosilica Nanoplatforms for Tumor-Specific Self-Assembly and Synergistic Therapy[J]. ACS nano, 2018, 12(12): 12269-12283. 14、Yang Z, Fan W, Tang W, et al. Near‐Infrared Semiconducting Polymer Brush and pH/GSH‐Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor‐Specific Phototheranostics[J]. Angewandte Chemie, 2018, 130(43): 14297-14301. 15、Chow S Y S, Wong R C H, Zhao S, et al. Disulfide‐Linked Dendritic Oligomeric Phthalocyanines as Glutathione‐Responsive Photosensitizers for Photodynamic Therapy[J]. Chemistry#8211;A European Journal, 2018, 24(22): 5779-5789.

3. 毕业设计（论文）进程安排

3月1日-3月15日 课题准备阶段，对相关英文文献进行阅读和翻译，撰写实验计划和开题报告 3月16日-4月底 材料合成阶段，合成系列中间体和DPP衍生物，确认分子结构 4月底-5月中旬 材料性质表征阶段，纳米材料的制备和表征、测试材料的光学性质和光热性能、研究过氧化氢和谷胱甘肽响应性质 5月中旬-6月初 论文撰写和答辩