1. 毕业设计（论文）的内容和要求

掌握过渡金属催化合成的方法和原理，熟悉联烯磷化合物的各种合成方法，掌握合成反应的实验操作，完成合成合成新反应的实验及数据整理工作。

2. 参考文献

1. Y. Gao, G. Wang, L. Chen, P. Xu, Y. Zhao, Y. Zhou and L.-B. Han, Copper-catalyzed aerobic oxidative coupling of terminal alkynes with H-phosphonates leading to alkynylphosphonates, J. Am. Chem. Soc., 2009, 131, 7956. 2. M. Kalek, T. Johansson, M. Jezowska and J. Stawinski, Palladium-catalyzed propargylic substitution with phosphorus nucleophiles: efficient, stereoselective synthesis of allenylphosphonates and related compounds, Org. Lett., 2010, 12, 4702. 3. F. Yu, X. Lian, J. Zhao, Y. Yu and Ma, S. CuX2-mediated halolactonization reaction of monoesters of 1,2-allenyl phosphonic acids and their suzuki cross-coupling reaction, J. Org. Chem., 2009, 74, 1130. 4. B. Xiong, R. Shen, M. Goto, S.-F. Yin and L.-B. Han,Highly selective 1,4- and 1,6-addition of P(O)-H compounds to p-quinones: A divergent method for the synthesis of C- and O-phosphoryl hydroquinone derivatives, Chem. Eur. J., 2012, 18, 16902. 5. C. S. Demmer, N. Krogsgaard-Larsen, L. Bunch, Review on modern advances of chemical methods for the introduction of a phosphonic acid group, Chem. Rev., 2011, 111, 7981.

3. 毕业设计（论文）进程安排

2月，文献调研，论文翻译。

3月-5月，实验工作。

5月末整理数据，撰写论文。