1. 毕业设计（论文）的内容和要求

1.熟悉基本的实验操作，理解实验的基本内容; 2.能做做到流利阅读文献，掌握文献内容; 3.熟练运用各种信息平台查阅相关信息; 4了解实验室的硬件设备上，有各种各样实验所需的药品和玻璃仪器，旋转蒸发仪，分析天平，低温反应器，400M超导核磁共振仪等实验设备.

2. 参考文献

[1]Yin. H. F.; Skrydstrup. T.; Johansen. M. K.; Development of a Palladium-Catalyzed Carbonylative Coupling Strategy to 1,4-Diketones. ACS Catal. 2016, 6, 2982#8722;2987. [2]Schmidt. N. G.; Eger. E.; Kroutil. W.; Bridges. B.; Biocatalytic C#8722;C Bond Formation toward Multifunctional Products. ACS Catal. 2016, 6, 4286#8722;4311. [3]Kamal. A.; Faazil. S.; Malik. M. S; Balakrishna. M.; Alarifi. A.; Convenient synthesis of substituted pyrroles via a cerium (IV) ammonium nitrate (CAN)-catalyzed Paal#8211;Knorr reaction. Arabian Journal of Chemistry. 2016, 9, 542-549. [4]Jacob R. Stepherson.; Frank R. Fronczek.; Rendy. Kartika.; An expedient synthesis of functionalized 1,4-diketone-derived compounds via silyloxyallyl cation intermediates. Chem. Commun. 2016, 52, 2300-2303. [5]Liang. X. T.; You. T.; Li. Y. H.; Yu. H. X.; Yang. Z.; Asymmetric Total Synthesis of Propindilactone G, Part 3: The Final Phase and Completion of the Synthesis. Chem. Asian. J. 2016, 11, 1425-1435. [6]Hsu. D. S.; Chen. C. H; Hsu. C. W; Synthesis of Spiranes by Thiol-Mediated Acyl Radical Cyclization. Eur. J. Org. Chem. 2016, 589-598. [7] Irina, Geibel.; Jens, Christoffers.; Synthesis of 1,4-Diketones from ?-Oxo Esters and Enol Acetates by Cerium-Catalyzed Oxidative Umpolung Reaction. Eur. J. Org. Chem. 2016, 918-920. [8]Soraya. Alnabulsi.; Elham. Santina.; Ilaria. Russo.; Sally.Freeman.; Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria. European Journal of Medicinal Chemistry. 2016, 111, 33-45. [9] Nirmal K, Mitra.; Rolande, Meudom.; Hector H, Corzo.; John D. Gorden.; Bradley L. Merner; Overcoming Strain-Induced Rearrangement Reactions: A Mild Dehydrative Aromatization Protocol for Synthesis of Highly Distorted p-Phenylenes. J. Am. Chem. Soc. 2016, 138, 3235#8722;3240. [10]Miao, C. B.; Zen,. Y. M.; Rui Liu. T. S.; Wei. P. F.; Sun. X. Q.; Yang. H. T.; 2-Oxindole Acts as a Synthon of 2-Aminobenzoyl Anion in the K2CO3-Catalyzed Reaction with Enones: Preparation of 1,4-Diketones Bearing an Amino Group and Their Further Transformations. J. Org. Chem. 2016, 81, 43#8722;50. [11] Irina Geibel.; Anna Dierks.; Marc Schmidtmann.; Jens Christoffers.; Formation of δ#8209;Lactones by Cerium-Catalyzed, Baeyer#8722;Villiger-Type Coupling of β-Oxoesters, Enol Acetates, and Dioxygen. J. Org. Chem. 2016, 81, 7790#8722;7798. [12] Leila, O. Khafizova.; Mariya, G. Shaibakova.; Usein M. Dzhemilev.; Effective one-pot synthesis of 2,3-dialkyl-1,4-dicyclopropyl-butane-1,4-diones catalyzed by Cp 2 TiCl 2. Mendeleev Commun. 2016, 26, 223-225. [13]Cecilia A. Barrionuevo.; LucianaC. Schmidt.; JuanE. Arguello.; Unexpected formation of 4,4-dimethyl-1,2-disubstituted-dicarbonyl cyclopentanes fromketone enolate anions and 1,3-diiodo-2,2-dimethylpropane. New. J. Chem., 2016, 40, 4550-4555. [14]Liu. Y. J.; Zhao. H.; Tian. G.; Du. F.; Qi. Y.; Wen. Y. H.;A novel coupling reaction of a-halo ketones promoted by SmI 3 /CuI; RSC Adv. 2016, 6, 26317-26322. [15]Nora. Dittrich.; Eun-Kyung. Jung.; Samuel. J. Davidson.; David. Barker.; N. Dittrich et al. An acyl-Claisen/Paal-Knorr approach to fully substituted pyrroles. Tetrahedron, 2016, 72, 4676-4689.

3. 毕业设计（论文）进程安排

2017.2 进入实验室，交待相关事宜，安排实验任务； 2017.2-2017.3 查阅文献，准备开题报告； 2017.3.3 提交开题报告； 2017.3-2017.4 合成试验所需原料； 2017.4-2017.6 选择相应的催化剂催化反应进行，筛选条件，优化反应条件； 2017.5-2017.6 实验数据,整理与分析； 2017.6 撰写论文， 论文答辩。