1. 毕业设计（论文）的内容和要求

论文内容： 阿尔兹海默症（ad）是一种渐进的神经退行性紊乱疾病，它主要发生在老年人群中。

ad的病理学特征主要是β-淀粉样蛋白（aβ）的聚集，其聚集体特别是寡聚体的神经毒性被一致认为是导致ad的主要原因。

而且aβ的寡聚早在ad临床症状出现前既已发生。

2. 参考文献

[1] 林逢春，闰也. 阿尔茨海默病发病机制研究的现状与进展 [J]. 辽宁医学院学报. 2009, 30(6): 558-560. [2] 张于，程伟. 中西医治疗阿尔兹海默病的研究现状[J].中医临床研究. 2012，4(13): 115-117. [3] Hardy J, Selkoe D J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics [J]. Science. 2002, 297: 353-356. [4] Ittner L M, G#246;tz J. Amyloid-β and tau #8211; a toxic pas de deux in Alzheimer's disease [J]. Nat. Rev. Neurosci. 2011, 12: 67-72. [5] Faller P, Hureau C. Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide [J]. Dalton Trans. 2009, 7: 1080#8210;1094. [6] Miller Y, Ma B, Nussinov R. Zinc ions promote Alzheimer Aβ aggregation via population shift of polymorphic states [J]. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(21): 9490#8210;9495. [7] T#245;ugu V, Tiiman A, Palumaa P. Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity [J]. Metallomics 2011, 3(3): 250#8210;261. [8] Opazo C, Huang X D, Cherny R A. Metalloenzyme-like activity of Alzheimer's disease β-amyloid [J]. J. Biol. Chem. 2002, 277(43): 40302-40308. [9] Jiang D L, Men L J, Wang J X. Redox Reactions of Copper Complexes Formed with Different β -Amyloid Peptides and Their Neuropathalogical Relevance [J]. Biochemistry 2007, 46(32): 9270-9282. [10] Zhu X, Su B, Wang X. Causes of oxidative stress in Alzheimer disease [J]. Cell. Mol. Life Sci. 2007, 64(17): 2202-2210. [11] Bramblett G T, Goedert M, Jakes R. Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding [J]. Neuron, 1993, 10(6): 1089-1099. [12] Mandelkow E M, Mandelkow E. Tau in Alzheimer's disease [J]. Trends Cell Biol, 1998, 8(11): 425-427. [13] Cruz J C, Tsend H C, Goldman J A. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles [J]. Neuron, 2003, 40(3): 471-483. [14] Jack C R, Albert M S, Knopman D S, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J]. Alzheimers Dement, 2011, 7(3): 257-262. [15] 郭起浩，王蓓，洪震. ADAS评估阿尔茨海默病的认知功能研究 [J]. 神经疾病与精神卫生. 2009, 3(4): 251-251. [16] Federmeier K D, Kutas M. Aging in context: Age-related changes in context use during language comprehension [J]. Psychophysiology, 2005,42 (2), 133#8211;141. [17] Flirski M, Sobow T. Biochemical markers and risk factors of Alzheimer's disease [J]. Curr Alzheimer Res. 2005, 2(1): 47-64. [18] Cai L, Innis R B, Pike V W. Radioligand development for PET imaging of β-amyloid (Aβ)-current status [J]. Curr. Med. Chem. 2007, 14(1): 19-52. [19] Quigley H, Colloby S J, O#8217;Brien J T, et al. PET imaging of brain amyloid in dementia: a review [J]. Psychiatry, 2011, 26(10): 991-999. [20] Rowe C C, Villemagne V L. Brain amyloid imaging [J]. J. Nucl. Med. 2011, 52(11): 1733-1740.

3. 毕业设计（论文）进程安排

2017.11.1-2017.12.22查阅相关文献 2017.12.23-2018.1.12完成外文文献翻译和开题报告 2018.1.13-2018.2.15 实验前期准备（包括所需试剂原料、实验耗材的采购） 2018.2.15-2018.3.15探针的设计、合成与表征 2018.3.15-2018.4.15探针的性质测试 2018.4.15-2018.6.7实验数据处理并撰写毕业论文