1. 毕业设计（论文）的内容和要求

恶性肿瘤是威胁人类健康的主要杀手，阿霉素作为一种广谱抗肿瘤药物，在临床上有着广泛的应用，成为治疗乳腺癌、卵巢癌等恶性肿瘤的首选用药。

然而，阿霉素的选择性低、毒副作用大，具有明显的剂量依赖性心脏毒性，而且肿瘤细胞对阿霉素易产生耐药。

已有研究表明，肿瘤细胞摄取多不饱和脂肪酸的量远高于正常细胞。

2. 参考文献

[1] Lanzmann-Petithory D. Alpha-linolenic acid and cardiovascular diseases. J Nutr Health Aging. 2001, 5(3): 179 #8211; 183. [2] Gwendolyn Barcel#243;-Coblijn, Eric J, Murphy. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: Benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Progress in Lipid Research. 2009, 48(6): 355#8211;374. [3] K Prasad, SV, Mantha AD, et al. Reduction of hypercholesterolemic atherosclerosis by CDC-flaxseed with very low alpha-linolenic acid. Atherosclerosis. 1998, 136(2): 367#8211;375. [4] Paul Wilkinson, Clare Leach, Eric E,et al. Influence of α-linolenic acid and fish-oil on markers of cardiovascular risk in subjects with an atherogenic lipoprotein phenotype. Atherosclerosis. 2005, 181(1): 115#8211;124. [5] V Klein, V ChajeAacute; s, E Germain, et al. Low alpha-linolenic acid content of adipose breast tissue is associated with an increased risk of breast cancer. European Journal of Cancer. 2000, 36(3): 335-340. [6] Pizer, ES Lax, F Kuhajda, et al. Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors. Cancer. 1998, 83(3): 528-537. [7] Bemelmans WJ, Broer J, Feskens EJ, et al. Effect of an increased intake of alpha-linolenic acid and group nut ritional education on cardiovacular risk factors: the mediterranean alpha-linolenic enriched groningen dietary intervention study. Am. J. Clin. Nutr. 2002, 75(2): 221 #8211; 227. [8] Jaracz S, Chen J, Kuznetsova LV, et al. Recent advances in tumor-targeting anticancer drug conjugates. Bioorg Med Chem. 2005, 13(17): 5043-54. Review.

3. 毕业设计（论文）进程安排

2018.12.1-12.5 与导师会面，布置论文题目及要求 12.6-12.21 申报毕业设计题目，下达任务书，做好开题前期工作 12.22-2018.1.18 完成外文翻译、文献综述和开题报告 1.19-3.1 前药合成，计算产率 3.2-4.30 材料结构及性质的表征 4.31-5.31 数据整理，书写论文,制作PPT 6.1-6.10 准备论文答辩