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毕业论文网 > 任务书 > 化学化工与生命科学类 > 轻化工程 > 正文

聚谷氨酸基微纳米纤维排列方式与细胞粘附作用研究任务书

 2020-06-04 20:19:18  

1. 毕业设计(论文)的内容和要求

取向纤维结构使材料具有力学各向异性,提高纤维材料的取向
性,可以调控细胞运动功能。本课题主要以可降解聚谷氨酸为主要原料,聚氧化乙烯为辅助原料,制备微纳米纤维组织工程支架,通过控制纤维的排列方式研究其对细胞粘附及铺展性能的影响。

1. 具备高分子材料分子表征和纺丝液配制的能力 2. 掌握微纳米纤维表征和制备方法 3. 具备评价细胞相容性实验操作能力

2. 参考文献

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Collagen fibril diameters in the healing adult rabbit medial collateral ligament,
Connect. Tissue Res. 27 (4) (1992) 251e263. PM:1576825.
[3] C. Frank, D. McDonald, N. Shrive, Collagen fibril diameters in the rabbit medial
collateral ligament scar: a longer term assessment, Connect. Tissue Res. 36 (3)
(1997) 261e269. PM:9512894.
[4] C.J. Doillon, M.G. Dunn, E. Bender, F.H. Silver, Collagen fiber formation in repair
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[5] T.W. Lin, L. Cardenas, L.J. Soslowsky, Biomechanics of tendon injury and repair,
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[6] K.A. Hildebrand, C.B. Frank, Scar formation and ligament healing, Can. J. Surg.
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[9] C.H. Lee, H.J. Shin, I.H. Cho, Y.M. Kang, I.A. Kim, K.D. Park, J.W. Shin, Nanofiber
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3. 毕业设计(论文)进程安排

1. 2016.12-2017.1 文献调研及路线设计; 2. 2017.2-2017.6 材料制备及性能表征优化; 3. 2017.6 数据整理及论文写作。

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