1. 毕业设计（论文）的内容和要求

葡萄糖二酸 (glucaric acid， 简称 ga) 是一 种无毒的葡萄糖衍生物，天然存在于葡萄柚、 苹果、橘子等水果和十字花科蔬菜中，在少量 哺乳动物及人体内也有分泌。

早在 1964 年， 就有学者提出补充糖醛酸类物质，可能有利于 提高人体的自然防御机制，有助于消除致癌物 质，减少癌症病发的风险。

随着研究的深入， 葡萄糖二酸及其衍生物#8212;#8212;葡萄糖二酸 1,4-内 酯 (dsl) 因其在降低胆固醇、调控人体内激素 水平等方面发挥的作用逐渐受到医学界的重 视。

2. 参考文献

[1] Walaszek Z, Szemraj J, Hanausek M, et al. D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat. Nutr Res, 1996, 16(4): 673#8211;681. [2] Marsh CA. Metabolism of D-glucuronolactone in mammalian systems. 2. Conversion of D-glucuronolactone into D-glucaric acid by tissue preparations. Biochem J, 1963, 87(1): 82#8211;90. [3] Chen L, Kiely DE. D-Glucaric acid esters/lactones used in condensation polymerization to produce hydroxylated nylons-a qualitative equilibrium study in acidic and basic alcohol solutions. J Carbohyd Chem, 1994, 13(4): 585#8211;601. [4] Smith T, Denton T, Zhang J, et al. Synthesis and characterization of higher molecular weight stereo-random poly (D-glucaramides) from 1: 1 alkylenediammonium D-glucaric acid//234th ACS National Meeting, Boston, MA, United States, 2007. [5] Henkensmeier D, Abele BC, Candussio A, et al. Synthesis, characterisation and degradability of polyamides derived from aldaric acids and chain end functionalised polydimethylsiloxanes. Polymer, 2004, 45(21): 7053#8211;7059. [6] Kiely DE. Carbohydrate acid amide plant fertilizers: US, 5478374. 1995-12-26. [7] Morton DW, Kiely DE. Evaluation of the film and adhesive properties of some block copolymer polyhydroxy polyamides from esterified aldaric acids and diamines. J Appl Polym Sci, 2000, 77(14): 3085#8211;3092. [8] Anonymous. Rivertop begins scaling up of glucaric acid production. Int Sugar J, 2012, 114(1361): 304.

3. 毕业设计（论文）进程安排

2.25-3.1 确定毕业设计的课题及相关资料的查找 3.2-3.10 实验方案的设计 3.10-3.20 实验材料的准备 3.21-5.10 工艺合成 5.10-6.5 实验数据处理与结果分析 5.20-6.10 毕业论文书写