1. 毕业设计（论文）的内容和要求

可注射型水凝胶在药物传递和组织工程领域中有着广阔的应用前景。

众所周知，水凝胶是模拟细胞外基质(ecm)用于细胞的三维封装的理想材料之一，它不仅能提供高度水合的组织环境，而且还具有生物活性物质(如生长因子)的掺入能力。

基于此，本课题提出了一个独特的方法，利用动态共价键和离子键的相互作用，来构建可注射型双网（dn）水凝胶，用于细胞3d培养及生物功能性的构建，并有望实现软骨组织工程方面的应用。

2. 参考文献

(1) Wang, H.; Heilshorn, S. C. Adaptable Hydrogel Networks with Reversible Linkages for Tissue Engineering.Adv. Mater.2015, 27, 3717#8722;3736. (2) Yang, J. A.; Yeom, J.; Hwang, B. W.; Hoffman, A. S.; Hahn, S. K. In Situ-forming Injectable Hydrogels for Regenerative Medicine.Prog. Polym. Sci.2014, 39, 1973#8722;1986. (3) Zhao, X.; Wu, H.; Guo, B.; Dong, R.; Qiu, Y.; Ma, P. X. Antibacterial Anti-Oxidant Electroactive Injectable Hydrogel as Self-Healing Wound Dressing with Hemostasis and Adhesiveness for Cutaneous Wound Healing.Biomaterials2017, 122,34#8722;47. (4) Li, Y.; Kilian, K. A. Bridging the Gap: From 2D Cell Culture to 3D Microengineered Extracellular Matrices. Adv. Healthcare Mater. 2015, 4, 2780#8722;2796. (5) Ma, P. X. Biomimetic Materials for Tissue Engineering.Adv. Drug Delivery Rev.2008, 60, 184#8722;198. (6) Balakrishnan, B.; Jayakrishnan, A. Self-Cross-Linking Biopol-ymers as Injectable in Situ Forming Biodegradable Scaffolds. Biomaterials2005, 26, 3941#8722;3951. (7) Yan, S.; Wang, T.; Feng, L.; Zhu, J.; Zhang, K.; Chen, X.; Cui, L.; Yin, J. Injectable in Situ Self-Cross-Linking Hydrogels Based on Poly(L-glutamic acid) and Alginate for Cartilage Tissue Engineering. Biomacromolecules2014, 15, 4495#8722;4508. (8) Dong, R.; Zhao, X.; Guo, B.; Ma, P. X. Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy.ACS Appl. Mater. Interfaces2016, 8, 17138#8722;17150

3. 毕业设计（论文）进程安排

1. 2017.12-2018.1 文献调研及路线设计； 2. 2018.2-2018.6 实验合成及工艺路线优化； 3. 2018.6 数据整理及论文写作。