1. 毕业设计（论文）的内容和要求

本课题从模仿生物体柔软、有弹性、可愈合的自然特性出发，基于聚谷氨酸材料设计具备良好组织贴合、弹性、自愈合，并且可促进皮肤软组织修复与再生的水凝胶体系，拟对其弹性模量、延展性和生物相容性进行表征和评价，在确定生物相容性基础上进行活体实验确定其临床应用效果

2. 参考文献

1. Irvine, A. D., McLean,W. H. Leung, D. Y. Filaggrin mutations associated with skin and allergic diseases. N. Engl. J. Med. 365, 13151327 (2011). 2. Li G, Wu J, Wang B, et al. Self-healing supramolecular self-assembled hydrogels based on poly (l-glutamic acid)[J]. Biomacromolecules, 2015, 16(11): 3508-3518. 3. Schon, M. P. Boehncke,W. H. Psoriasis. N. Engl. J. Med. 352, 18991912 (2005). 4. Bieber, T. Atopic dermatitis. N. Engl. J. Med. 358, 14831494 (2008). 5. Yosipovitch, G. Bernhard, J. D. Clinical practice. Chronic pruritus. N. Engl. J. Med. 368, 16251634 (2013). 6. Zhuang H, Hong Y, Gao J, et al. A poly (γ‐glutamic acid)‐based hydrogel loaded with superoxide dismutase for wound healing[J]. Journal of Applied Polymer Science, 2015, 132(23). 7. Balin, A. K. Pratt, L. A. Physiological consequences of human skin aging. Cutis 43, 431436 (1989). 8. Anderson, R. R. Lasers for dermatology and skin biology. J. Invest. Dermatol. 133, E21E23 (2013). 9.Gentilini C, Dong Y, May J R, et al. Functionalized Poly (γ‐Glutamic Acid) Fibrous Scaffolds for Tissue Engineering[J]. Advanced healthcare materials, 2012, 1(3): 308-315.

3. 毕业设计（论文）进程安排

1. 2018.12-2019.1 文献查询及路线设计； 2. 2019.2-2019.6 实验合成及工艺路线优化； 3. 2019.6 数据分析及论文撰写