1. 毕业设计（论文）的内容和要求

己内酯是一种重要的有机合成中间体和新型聚酯单体，其开环聚合所得的聚己内酯在生物医用材料、环境友好塑料等领域有广泛的用途。

根据生产工艺和原料使用的不同，己内酯合成的方法主要有环己酮氧化法、环己醇氧化法、己二酸环化法、1,6-己二醇脱氢法和6-羟基己酸分子内缩合法等。

综合各种因素的考虑，环己酮氧化法合成己内酯是目前最可行的方法。

2. 参考文献

[1] Gonzalez-Nunez, MR.; R, Mello.; A, Olmos.; G, Asensio. Beayer-Villiger oxidation with potassium peroxomonosulfate supported on acidic silica gel[J]. J. Org. Chem,2005,70,10879-10882. [2] Gonzalez-Nunez, ME.; R, Mello.; A, Olmos.; G, Asensio. Baeyer-Villiger oxidation in supercritical CO2 with potassium peroxomonosulfate supported on acidic silicagel[J].J.Org.Chem,2006,71,6432-6436. [3] Filippis, PD.; M, Scarsella. Functionalized hexagonal mesoporous silica as an oxidizing agent for the oxidative desulfurization of organosulfur compounds[J]. Ind. Eng.Chem.Res,2008,47,973-975. [4] Mello, R.; A, Olmos.; J, Parra-Carbonell.; M, Elena Gonzalez-Nunez.; G, Asensio. Baeyer-Villiger oxidation of ketones with a silica-supported peracid in supercritical carbon dioxide under flow conditions[J]. Green Chem, 2009, 11, 994-999. [5] Mello, R.; A, Olmos.; A, Alcalde-Aragones.; A, Diaz-Rodriguez.; M, Elena Gonzalez Nunez.; G, Asensio. Oxidation of sulfides with a silica-supported peracid in supercritical carbon dioxide under flow conditions: tuning chemoselectivity with pressure[J].Eur.J.Org.Chem,2010,6200-6206. [6] Davarpanah, J.; A, Reza Kiasat.; Synthesis and characterization of SBA-polyperoxyacid: an efficient heterogeneous solid peroxyacid catalyst for epoxidation of alkenes[J]. Catalysis communications, 2014, 46, 75-80. [7] Elings, JA.; R, Ait-Meddour.; J, H. Clark.; D, J. Macquarrie. Preparation of a silica-supported peroxycarboxylic acid and its use in the epoxidation of alkenes[J]. Chem.Commun,1998,2701-2708. [8] Michael, R.; M, Bernard. 100 years of Baeyer-Viliger oxidations[J]. J. Org. Chem. 1999,4,737-750. [9] Krow, Grant R. The Baeyer-Viliger oxidation of ketones and aldehydes[J]. Organic reactions. 1993, 43, 251-798. [10] 曹涤尘. 有机过氧酸的合成和利用[J]. 江苏化工，1983（01） [11] Mihovilovic, Marko D. Enzyme mediated Baeyer-Viliger oxidations[J]. Org. Chem, 2006, 10(11), 1265-1287. [12] Brink, G. J. Ten.; Arends, I. W. E.; Sheldon, R. A. The Baeyer-Viliger reaction: New developments toward greener procedures[J]. Chem. Rev, 2004, 104(9),4105-4123. [13] Carsten, B.; P, Chiara.; F, Giancarlo.; L, Walter. Baeyer-Viliger oxidation in compressed CO2[J]. Chem. Commun, 2002, 15, 1588-1589. [14] 赵小双. 固体过氧酸氧化环己酮合成己内酯工艺的研究[D]. 武汉理工大学， 2012. [15] Kropp, P. J.; G, W. Breton.; J, D. Fields.; J, C. Tung.; B, R. Loomis. Surface-Mediated Reaction. 8. Oxidation of sulfides and sulfoxides with tert-butyl hydroperoxide and OXONE[J]. J. Am. Chem. Soc, 2000, 122, 4280-4285.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 1.1-1.15 确定毕业设计的课题及相关资料的查找 2.22-3.10 实验方案的设计 3.10-3.20 实验材料的准备 3.21-5.10 工艺合成 5.10-6.5 实验数据处理与结果分析 5.20-6.10 毕业论文书写