1. 毕业设计（论文）的内容和要求

1．文献查阅 掌握文献查阅的一般方法，学会使用计算机在中国期刊网、维普数据库、超星数字图书馆、美国化学学会（acs）数据库、英国皇家化学学会（rcs）数据库、elseiver、isi chemistry server、ei、ca 等检索资源上查阅有关原料合成的相关文献。

2．文献阅读及综述 阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

[1] Wu W B, Huang J M. Highly Regioselective C-N Bond Formation through C-H Azolation of Indoles Promoted by Iodine in Aqueous Media [J]. Organic Letters, 2012. 14(23): 5832-5835. [2] Poirier M, Goudreau S, Poulin J. Metal-free Coupling ofAzoles with 2-and 3-haloindoles Providing Access to Novel 2-or 3-(azol-l-yl) Indole Derivatives[J]. Organic Letters, 2010, 12(10): 2334-2337. [3] Shiguang P, Naoto R, Takanori S. Ir(I)-Catalyzed C-H Bond Alkylation of C2-Position of ndole with Alkenes: Selective Synthesis of Linear or Branched 2-Alkylindoles[J]. Journal of the American Chemical Society, 2012, 134(42):17474-17477. [4] Benjamin S L, Meghann A, and Dalibor S. Direct Palladium-Catalyzed C-2 and C-3 Arylation of Indoles: A Mechanistic Rationale for Regioselectivity [J]. Journal of the American Chemical Society, 2005, 127(22): 8050-8057. [5] Kochanowska-Karamyan A J, Hamann M T. Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety [J]. Chemical Reviews, 2010, 110(8): 4489-4497. [6] Hamlin K E, Fischer F E. The Synthesis of 5-hydroxytryptamine [J]. Journal of the American Chemical Society, 1951, 73(10): 5007-5008. [7] Cuny G D, Ulyanova N P, Patnaik D. Structure-activity Relationship Study of Beta-carboline Derivatives as Haspin Kinase Inhibitors[J]. Bioorganic Medicinal Chemistry Letters, 2012, 22(5):2015-2019. [8] Williams Theresa M, Ciccarone Terrence M, MacTough Suzanne C, Rooney Clarence S, Balani Suresh K, Condra Jon H, Emini Emilio A, Goldman Mark E, Greenlee William J. 5-Chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase[J]. Journal of Medicinal Chemistry, 1993, 36(9): 1291-4. [9]Bernotas R, Lenicek S, Antane S, Zhang G M, Smith D, Coupet J, Harrison B, Schechter L E. 1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands[J]. Bioorganic Medicinal Chemistry Letters, 2004, 14(22):5499-5502. [10] Yadav J S, Reddy B V S, Krishna A. D, Swamy T. InBr3-catalyzed sulfonation of indoles: a facile synthesis of 3-sulfonyl indoles [J]. Tetrahedron Letters, 2003, 44(32):6055-6058. [11]Rahman, M; Ghosh, M; Hajra, A; Majee, A. A simple and efficient approach for the sulfonylation of indoles catalyzed by CuI[J]. Journal of Sulfur Chemistry, 2013, 34(4), 342-346. [12] Yang, Y; Li, W; Xia, C; Ying, B; Shen, C; Zhang, P. Catalyst-Controlled Selectivity in C-S Bond Formation: Highly Efficient Synthesis of C2- and C3-Sulfonylindoles ChemCatChem, 2016, 8(2), 304-307. [13] Boroujeni, K P. Sulfonylation of aromatic compounds with sulfonic acids using silica gel-supported AlCl3 as a heterogeneous Lewis acid catalyst [J]. Journal of Sulfur Chemistry 2010, 31(3), 197-203. [14] Chen, M; Huang, Z-T; Zheng, Q-Y. Visible light-induced 3-sulfenylation of N-methylindoles with arylsulfonyl chlorides[J]. Chemical Communication, 2012, 48(95), 11686-11688. [15] (a) Jain A, Gupta Y, Jain S K. Azo chemistry and its potential for colonic delivery. Critical Reviews in Therapeutic Drug Carrier Systems, 2006, 23(5): 349-399. (b) Wu M, Cao Y, Zhang X, Zhang Y, Chen Yong, He Liu, Qian Z. Double "plug and play" templates technology for photo controllable drug release polyelectrolyte multilayers[J]. Chemical Communications, 2012, 48(79):9846-9848.

3. 毕业设计（论文）进程安排

2018.1.12~2018.3.19 查阅文献，做出研究方案，完成外文翻译和开题报告，开始实验 2018.3.20~2018.3.24 总结前一阶段工作，完成中期自检和中期汇报，确定下一阶段目标 2018.3.25~2018.4.30 扩展课题研究范围，改进实验方案，对 数据整理分析，撰写论文 2018.5.1~2018.6.7 完善毕业论文 2018.6.7~2018.6.14 准备毕业答辩