1. 毕业设计（论文）的内容和要求

一、论文内容： 1,5戊二胺又名戊二胺、尸胺、1,5-二氨基戊烷。

在工业上，戊二胺具有广泛的应用前景。

用戊二胺和不同碳链长的二元酸聚合可以得到不同的新型聚酰胺如聚酰胺54、聚酰胺56等。

2. 参考文献

[1] Kelly M T, Blaise A, Larroque M. Rapid automated high performance liquid chromatography method for simultaneous determination of amino acids and biogenic amines in wine, fruit and honey[J]. Journal of chromatography A, 2010, 1217(47): 7385-7392. [2] Manuel J, Zhanel G G, de Kievit T. Cadaverine suppresses persistence to carboxypenicillins in Pseudomonas aeruginosa PAO1[J]. Antimicrobial agents and chemotherapy, 2010, 54(12): 5173-5179. [3] Kind S, Jeong W K, Schr#246;der H, et al. Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane[J]. Metabolic engineering, 2010, 12(4): 341-351. [4] Kind S, Kreye S, Wittmann C. Metabolic engineering of cellular transport for overproduction of the platform chemical 1, 5-diaminopentane in Corynebacterium glutamicum[J]. Metabolic engineering, 2011, 13(5): 617-627. [5] Park J H, Lee S Y. Metabolic pathways and fermentative production of L‐aspartate family amino acids[J]. Biotechnology journal, 2010, 5(6): 560-577. [6]]Riedel C, Rittmann D, Dangel P, et al. Characterization of the phosphoenolpyruvate carboxykinase gene from Corynebacterium glutamicum and significance of the enzyme for growth and amino acid production[J]. Journal of molecular microbiology and biotechnology, 2001, 3(4): 573-583. [7]Qian Z G, Xia X X, Lee S Y. Metabolic engineering of Escherichia coli for the production of cadaverine: a five carbon diamine[J]. Biotechnology and bioengineering, 2011, 108(1): 93-103. [8] N#230;rdal I, Pfeifenschneider J, Brautaset T, et al. Methanol‐based cadaverine production by genetically engineered Bacillus methanolicus strains[J]. Microbial biotechnology, 2015, 8(2): 342-350. [9] Becker J, Zelder O, H#228;fner S, et al. From zero to hero#8212;design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production[J]. Metabolic engineering, 2011, 13(2): 159-168. [10] Contador C A, Rizk M L, Asenjo J A, et al. Ensemble modeling for strain development of L-lysine-producing Escherichia coli[J]. Metabolic engineering, 2009, 11(4-5): 221-233. [11]Tateno T, Okada Y, Tsuchidate T, et al. Direct production of cadaverine from soluble starch using Corynebacterium glutamicum coexpressing amylase and lysine decarboxylase[J]. Applied microbiology and biotechnology, 2009, 82(1): 115.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 2018.12.12-12.18 选题，与导师讨论题目 2018.12.21 导师下达任务书 2018.12.21-2019.1.18 根据任务书要求，查找相关文献资料，完成任务书 2019.01.18-2019.02.23 提交开题报告 2019.02.23-05.23 完成试验并提交论文第一稿 2019.05.24-05.27 根据导师意见修改论文第一稿，完成并提交第二稿 2019.05.28-06.1 根据导师意见修改论文第二稿，完成并提交第三稿 2019.06.1-06.14 完成论文的审阅，准备答辩