1. 毕业设计（论文）的内容和要求

在本组开发的酶学数据底层框架的基础上，开发芳香族化合物氧化还原酶的子库，构建一个综合蛋白质序列、催化位点、结合位点与结合底物、3D结构表征及其功能注释的数据库。

最后，通过引入酶学突变数据，构建一个表征突变特性预测模型。

2. 参考文献

1. Davids, T., et al., Strategies for the discovery and engineering of enzymes for biocatalysis. Curr Opin Chem Biol, 2013. 17(2): p. 215-20. 2. Jacques, P., et al., High-throughput strategies for the discovery and engineering of enzymes for biocatalysis. Bioprocess Biosyst Eng, 2017. 40(2): p. 161-180. 3. Jeske, L., et al., BRENDA in 2019: a European ELIXIR core data resource. Nucleic Acids Res, 2018. 4. Lenfant, N., et al., ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins: tools to explore diversity of functions. Nucleic Acids Res, 2013. 41(Database issue): p. D423-9. 5. Placzek, S., et al., BRENDA in 2017: new perspectives and new tools in BRENDA. Nucleic Acids Res, 2017. 45(D1): p. D380-D388. 6. Rawlings, N.D., et al., The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database. Nucleic Acids Res, 2018. 46(D1): p. D624-D632.

3. 毕业设计（论文）进程安排

2月下旬-3月中旬：文献检索、数据准备。

3月中旬--5月中旬：构建、修正数据库，应用举例。

5月中旬--六月上旬：论文写作、答辩。