1. 毕业设计（论文）的内容和要求

本课题要求熟悉基本的理论知识，了解检测高血压症状是否得到缓解的指标，进一步验证智蓉温阳膏安脉饮治疗高血压的临床疗效，以及其临床用药的安全性，严格遵循临床试验方案对病人进行临床试验观察。

每个病例与给药前一天、治疗期间、疗程结束后两天内由观察者将病人的主要症状及各项指标检测按照相关标准进行判定，并及时进行个体病症疗效与安全性总结，并严格填写病例报告表

2. 参考文献

1.Xiong X, Yang X, Liu Y, Zhang Y, Wang P, Wang J.(2013)Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science. Hypertension research: official journal of the Japanese Society of Hypertension 2.Morton JS, Cooke CL, Davidge ST.（2015）In Utero Origins of Hypertension: Mechanisms and Targets for Therapy. Physiological reviews van den Meiracker AH. (2013)A global approach to hypertension. Euro Intervention 3.Iadecola C, Yaffe K, Biller J, Bratzke LC, Faraci FM, Gorelick PB, Gulati M, Kamel H, Knopman DS, Launer LJ, Saczynski JS, Seshadri S, Zeki Al Hazzouri A;American Heart Association Council on#8194;Hypertension; Council on Clinical Cardiology; Council on#8194;Cardiovascular#8194;Disease in the Young; Council onCardiovascular#8194;and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Stroke Council.(2016)Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association. Hypertension 4.Cameron AC, Lang NN, Touyz RM(2016).Drug Treatment of Hypertension: Focus on Vascular Health. Drugs 5.Yajing Xie , Wei Zhang（2013）Antihypertensive activity of Rosa rugosa Thunb. flowers: Angiotensin I converting enzyme inhibitor. American journal of hypertension 6.Jiarong Lan, Feixia Dong, Ziyou Yan, Wenjie Zheng, Jinping Fan, Guoli Sun(2014)Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes melitus, hyperlipemia and hypertension. journal of Ethnopharmacology 7.Xiong X, Yang X, Liu Y, Zhang Y, Wang P, Wang J.(2013)Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science. Hypertension research: official journal of the Japanese Society of Hypertension 8. Ahad A, Al-Mohizea AM, Al-Jenoobi FI, Aqil M.(2016)Transdermal delivery of angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme inhibitors (ACEIs) and others for management of hypertension. Drug delivery

3. 毕业设计（论文）进程安排

1. 实验方案确定：2018.2.20-2018.3.1 2. 志愿者招募：2018.3.1-2018.3.10 3. 方案实施，疗效观察，收集数据：2018.3.10-2018.5.10 4. 毕业论文撰写及答辩：2018.5.10-2018.6