1. 毕业设计（论文）的内容和要求

1．文献查阅 掌握文献查阅，使用网络资源如中国期刊网、维普数据库、超星数字图书馆、elsevier电子期刊、pub med等全文电子期刊等检索资源，查阅关于雷公藤甲素、紫云英苷以及小鼠睾丸损伤方面的相关文献。

2．文献阅读及综述 阅读与课题相关的外文与中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

[1]、 LIU Q. Triptolide and its expanding multiple pharmacological functions[J]. Int Immunopharmacol, 2011, 11(3): 377-383. [2]、 LI X X, DU F Y, LIU H X, et al. Investigation of the active components in Tripterygium wilfordii leading to its acute hepatotoxicty and nephrotoxicity[J]. J Ethnopharmacol, 2015, 162: 238-243. [3]、 LIU L, JIANG Z, LIU J, et al. Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats[J]. Toxicology, 2010, 271(1/2): 57-63. [4]、 LI J, JIN J, LI M, et al. Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells[J]. Toxicol Lett, 2012, 213(2): 194-202. [5]、 TAN B J, CHIU G N C. Role of oxidative stress, endoplasmic reticulum stress and ERK activation in triptolide-induced apoptosis[J]. Int J Oncol, 2013, 42(5): 1605-1612. [6]、 CHOI J, KANG H J, KIM S Z, et al. Antioxidant effect of astragalin isolated from the leaves of Morus alba L. against free radical-induced oxidative hemolysis of human red blood cells[J]. Arch Pharm Res, 2013, 36(7): 912-917. [7]、 SOROMOU L W, CHEN N, JIANG L, et al. Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-κB signaling pathway[J]. Biochem Bioph Res Co, 2012, 419(2): 256-261. [8]、 张银娣, 沈建平, 王幼林, 等. 黄芪苷抗生物氧化作用的研究[J]. 中药药理与临床, 1991 (6): 14-17. [9]、 李素娟, 邢艳刚, 薛星晨, 等. 氟对小鼠睾丸谷胱甘肽抗氧化系统的影响[J]. 畜牧兽医学报, 2017, 48(5): 954-962. [10]、 OTT M, GOGVADZE V, ORRENIUS S, et al. Mitochondria, oxidative stress and cell death[J]. Apoptosis, 2007, 12(5): 913-922. [11]、 WANG Y, GUO S, SHANG X, et al. Triptolide induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response[J]. Acta Pharmacol Sin, 2018, 39(2): 311.

3. 毕业设计（论文）进程安排

无