1. 毕业设计（论文）的内容和要求

一、内容 1莫沙必利干混悬剂释放度方法 2莫沙必利干混悬剂处方筛选及工艺研究 3莫沙必利干混悬剂初步处方及工艺的拟定 4莫沙必利干混悬剂体外释放度测定 5莫沙必利干混悬剂沉降体积比的测定 一、 要求 1．文献查阅 掌握文献查阅的一般方法，学会使用计算机在中国期刊网、维普数据库、超星数字图书馆、美国化学学会(acs)数据库、ca、sci等检索资源上查阅关于醋酸奥曲肽微球的相关文献。

2．文献阅读及综述 阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

[1] A Dahan, A Hoffman. Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs[J]. J. Controlled Release, 2008,129(1):1~10. [2] A Singh, Z A Worku, G Van den Mooter. Oral formulation strategies to improve solubility of poorly water-soluble drugs[J]. Expert Opin. Drug Delivery, 2011,8(10):1361~1378. [3] H D Williams, N L Trevaskis, S A Charman, et al. Strategies to Address Low Drug Solubility in Discovery and Development[J]. Pharmacol. Rev., 2013,65(1):315~499. [4] G A Fridgeirsdottir, R Harris, P M Fischer, et al. Support Tools in Formulation Development for Poorly Soluble Drugs[J]. J. Pharm. Sci., 2016,105(8):2260~2269. [5] A Dahan, A Beig, D Lindley, et al. The solubility-permeability interplay and oral drug formulation design: Two heads are better than one[J]. Adv. Drug Delivery Rev., 2016,101:99~107. [6] G L Amidon, H Lennernas, V P Shah, et al. A THEORETICAL BASIS FOR A BIOPHARMACEUTIC DRUG CLASSIFICATION - THE CORRELATION OF IN-VITRO DRUG PRODUCT DISSOLUTION AND IN-VIVO BIOAVAILABILITY[J]. Pharm. Res., 1995,12(3):413~420. [7] E Escribano, X Garcia Sala, J Salamanca, et al. Single-pass intestinal perfusion to establish the intestinal permeability of model drugs in mouse[J]. Int. J. Pharm., 2012,436(1-2):472~477. [8] I Lozoya-Agullo, I Gonzalez-Alvarez, M Gonzalez-Alvarez, et al. In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model[J]. J. Pharm. Sci., 2015,104(9):3136~3145. [9] S T Buckley, S M Fischer, G Fricker, et al. In vitro models to evaluate the permeability of poorly soluble drug entities: Challenges and perspectives[J]. Eur. J. Pharm. Sci., 2012,45(3):235~250. [10] 国家食品药品监督管理总局. 国务院关于改革药品医疗器械审评审批制度的意见[EB/OL]. http://www.sda.gov.cn/WS01/CL1749/126821.html. 2017/9/23

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 3-4至3-15 文献查询和资料阅读 3-16至4-9 研究方案制定和开题报告写作 4-10至5-20 实验研究过程 5-20至5-22 数据整理与处理、完善实验 5-22至6-4 论文写作与修改、成文