1. 毕业设计（论文）的内容和要求

1.文献查阅 学会利用计算机在中国期刊网、维普数据网、springerlink、ca、sci、elsevier等等网络检索资源上检索、查阅与普卡必利合成相关的文献，掌握文献查阅的方法。

2.文献阅读及综述 仔细阅读与所做课题相关的国内外文献，了解相关的背景知识以及目前国内外的研究动态，会系统分析，撰写文献综述。

3.明确实验任务，拟定实验方案 根据所查文献的内容，结合大学所学课程相关知识，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

[1]O#8217;Hagan, D.; Harper,D. B.Fluorine-containing natural products.[J] .J. Fluorine Chem. 1999, 100, 127. [2] Chambers, R. D. Fluorine in Organic Chemistry; Blackwell:Oxford, 2004. [3] Uneyama, K. Organofluorine Chemistry; Blackwell: Oxford, 2006. [4] Begue #769; , J.-P.; Bonnet-Delpon, D. #769; Bioorganic and Medicinal Chemistry of Fluorine;[J]. Wiley: New York, 2008. [5] Ojima, I. Fluorine in Medicinal Chemistry and Chemical Biology;Blackwell: Oxford, 2009. [6] Egli, M. The steric hypothesis for DNA replication and fluorine hydrogen bonding revisited in light of structural data.[J].Acc. Chem. Res. 2012, 45, 1237. [7] Littich, R.; Scott, P. J. H. Novel strategies for fluorine-18 radiochemistry.[J].Angew. Chem., Int. Ed. 2012, 51, 1106. [8] Cametti, M.; Crousse, B.; Metrangolo, P.; Milani, R.; Resnati, G.The fluorous effect in biomolecular applications.[J].Chem. Soc. Rev. 2012, 41, 31. [9] Salwiczek, M.; Nyakatura, E. K.; Gerling, U. I. M.; Ye, S.;Koksch, B.Fluorinated amino acids: compatibility with native protein structures and effects on protein#8211;protein interactions[J].Chem. Soc. Rev. 2012, 41, 2135. [10] (a) V.P. Kukhar, A.E. Sorochinsky, V.A. Soloshonok, Future Med.Practical synthesis of fluorine-containing α- and β-amino acids: recipes from Kiev, Ukraine.[J].Chem. 1 2009,793#8211;819; (b) A.E. Sorochinsky, V.A. Soloshonok,ChemInform Abstract: Asymmetric Synthesis of Fluorine-Containing Amines, Amino Alcohols, α- and β-Amino Acids Mediated by Chiral Sulfinyl Group[J].J. Fluor. Chem. 131 2010,127#8211;139; (c) J.L. Acena, A. Simon-Fuentes, S.Fustero,Recent Developments in the Synthesis of Fluorinated β-Amino Acids [J].Curr. Org. Chem. 14 2010, 928#8211;949; (d) K.Mikamia, S. Fusterob,c, M.S#225;nchez-Rosell#243;c, J.L. Acentilde;ac, V. Soloshonokd,e, A.Sorochinsky*fa, Synthesis of Fluorinated β-Amino Acids [J].Synthesis 2011,3045#8211;3079; [11]Y. Pan, S. Wang, C.W. Kee, E. Dubuisson, Y. Yang, K.P. Loh, C.-H. Tan, Graphene oxide and Rose Bengal: oxidative C-H functionalisation of tertiary amines using visible light.[J].Green Chem.13 2011,3341#8211;3344. [12]Yagupolskii, L. M.; Maletina, I. I.; Petko, K. I.; Fedyuk, D. V.;Handrock, R.; Shavaran, S. S.; Klebanov, B. M.; Herzig, S. New fluorine-containing hypotensive preparations[J].J. Fluorine Chem. 2001, 109, 87. [13]Hendrickson, J. B.; Bair, K. W. New methods for the synthesis of triflones[J].J. Org. Chem. 1977, 42, 3875. [14]Avdeenko, A. P.; Konovalova, S. A.; Mikhailichenko, O. N.;Shelyazhenko, S. V.; Pirozhenko, V. V.; Yagupol#8217;skii, L. M. Reactions of N-aryl (methyl,trifluoromethyl)sulfonyl-1,4-benzoquinone monoimines with sodium sulfinates[J]. Russ. J. Org.Chem. 2012, 48, 221. [15]Kolomeitsev, A. A.; Movchun, V. N; Kondratenko, N. V.;Yagupolski, Y. L.A.Convenient Route to Aryl Trifluoromethyl Sulfones by Fluoride-Catalyzed Cross-Coupling[J].Synthesis 1990, 1151. [16]Yagupolskii, L. M.; Matsnev, A. V.; Orlova, R. K.; Deryabkin, B.G.; Yagupolskii, Y. L.A new method for the synthesis of trifluoromethylating agents#8212;Diaryltrifluoromethylsulfonium salts [J].J. Fluorine Chem. 2008, 129, 131. [17]Yoshioka, E.; Kohtani, S.; Miyabe, H. Sequential reaction of arynes via insertion into the π-bond of amides[J].Org. Lett. 2010, 12, 1956. [18]Sekiya, A.; Umemoto, T.Synthesis and reactivity of trifluoromethylazosulfonylarenes.[J] Chem. Lett. 1982, 11, 1519. [19]Isobe, H.; Sato, S.; Tanaka, T.; Tokuyama, H.; Nakamura, E.Thermal and palladium-catalyzed [3 2] synthesis of cyclopentadienone acetals from cyclopropenone acetals and acetylenes.[J].Org. Lett. 2004, 6, 3569. [20]Beaumont, A. J.; Clark, J. H.Preparation and fluorination of aryltrifluoromethylsulphones[J].J. Fluorine Chem. 1991, 52, 295. [21]Chiba, J.; Sugihara, T.; Kaneko, C. Chem. Lett. 1995, 24, 581.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 备 注 11.01～11.15 接受任务，文献检索 11.16～1.15 文献资料整理及实验设计、开题报告 2.20～5.25 实验 5.26～5.28 实验数据的整理与补充 5.29～6.4 论文初稿 6.5～6.10 论文定稿 6.11～6.15 论文答辩、论文进一步修改