1. 毕业设计（论文）的内容和要求

1．文献查阅 掌握文献查阅的一般方法，学会使用计算机在中国期刊网，维普数据库，超星数字图书馆，elsevier电子期刊，springer link全文电子期刊，pubmed等检索资源上查阅pks酶的相关文献。

2．文献阅读及综述 阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

2. 参考文献

1.Staff T P O. Correction: Metabolic Engineering Camelina sativa with Fish Oil-Like Levels of DHA[J]. Plos One, 2014, 9(4):e95409. 2.James R. Petrie, Pushkar Shrestha, Srinivas Belide, Yoko Kennedy, Geraldine Lester, Qing Liu, Uday K. Divi, Roger J. Mulder, Maged P. Mansour, Peter D. Nichols, Surinder P. Singh. Metabolic Engineering Camelina sativa with Fish Oil-Like Levels of DHA[J]. Plos One, 2014, 9(1):e85061. 3.Davis P F, Ozias M K, Carlson S E, et al. Dopamine receptor alterations in female rats with diet-induced decreased brain docosahexaenoic acid (DHA): interactions with reproductive status[J]. Nutritional Neuroscience, 2015, 13(4):161-9. 4.Chauton M S, Reitan K I, Norsker N H, et al. A techno-economic analysis of industrial production of marine microalgae as a source of EPA and DHA-rich raw material for aquafeed: Research challenges and possibilities[J]. Aquaculture, 2015, 436:95-103. 5.Makrides M, Gould J F, Gawlik N R, et al. Four-year follow-up of children born to women in a randomized trial of prenatal DHA supplementation.[J]. Jama the Journal of the American Medical Association, 2014, 311(17):1802-4. 6.Patterson A C, Metherel A H, Hanning R M, et al. The percentage of DHA in erythrocytes can detect non-adherence to advice to increase EPA and DHA intakes.[J]. British Journal of Nutrition, 2014, 111(2):1-9. 7.Gurzell E A, Wiesinger J A, Morkam C, et al. Is the omega-3 index a valid marker of intestinal membrane phospholipid EPA DHA content? ☆[J]. Prostaglandins Leukotrienes Essential Fatty Acids, 2014, 91(3):87-96. 8.Mohajeri M H, Troesch B, Weber P. Inadequate supply of vitamins and DHA in the elderly: implications for brain aging and Alzheimer-type dementia.[J]. Nutrition, 2015, 31(2):261-75. 9.Juhyun S, Nayeon K, Mi-Hyang L, et al. Association of serum phospholipid PUFAs with cardiometabolic risk: beneficial effect of DHA on the suppression of vascular proliferation/inflammation.[J]. Clinical Biochemistry, 2014, 47(6):361-8. 10.Olsen Y, Evjemo J O, Kj#248;rsvik E, et al. DHA content in dietary phospholipids affects DHA content in phospholipids of cod larvae and larval performance[J]. Aquaculture, 2014, s 428#8211;429(5):203-214. 11.Gerardin J, Eckhoff P, Wenger E A. Mass campaigns with antimalarial drugs: a modelling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and elimination.[J]. BMC Infectious Diseases, 2015, 15(1):1-14. 12.Prostek A, Gajewska M, Kamola D. The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation[J]. Lipids in Health Disease, 2014, 13(1):3. 13..Mulder K A, King D J, Innis S M. Omega-3 fatty acid deficiency in infants before birth identified using a randomized trial of maternal DHA supplementation in pregnancy.[J]. Plos One, 2014, 9(1):e83764. 14.Ilyasoglu H, El S N. Nanoencapsulation of EPA/DHA with sodium caseinate#8211;gum arabic complex and its usage in the enrichment of fruit juice[J]. LWT - Food Science and Technology, 2014, 56(2):461#8211;468. 15.Pauter A M, Olsson P, Asadi A, et al. Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice[J]. Journal of Lipid Research, 2014, 55(4):718-28. 16.Amiri-Jami M, Lapointe G, Griffiths M W. Engineering of EPA/DHA omega-3 fatty acid production by Lactococcus lactis, subsp. cremoris, MG1363[J]. Applied Microbiology and Biotechnology, 2014, 98(7):3071-80.

3. 毕业设计（论文）进程安排

起讫日期 设计（论文）各阶段工作内容 备 注 12.30-01.30 查阅文献，完成开题报告 01.30#8212;03.01 完成英文翻译 03.01-05.30 完成实验工作 06.01-06.10 完成毕业论文